中国人兽共患病学报2012，Vol.28Issue(8)：792-794,3.DOI:10.3969/cjz.j.issn.1002-2694.2012.08.006
降钙素原在结核病诊断的价值
Value of procalcitonin in the diagnosis of tuberculosis
摘要
Abstract
Tuberculosis control has not benefited substantially from technological development over the past 100 years. The diagnostic tools are largely the same as in the early nineteenth century. Procalcitonin is a useful marker for severe systemic bacterial infections such as sepsis. Research on PCT level in the TB infection is limited. The aim of the study was to evaluate the diagnostic and prognostic value of PCT in the TB infection. The patients with the TB infection were divided into three groups: active pulmonary TB, non-active pulmonary TB, and extrapulmonary TB. Serum PCT level was measured by enzyme-linked immunosorbent assay (ELISA). The diagnostic and prognostic values of PCT in the TB infection were determined by receiver operating characteristic curve (ROC). The ELISA results showed that level of PCT was significantly increased in the active pulmonary TB group compared with the other TB groups and the healthy controls (P＜0. 05＝. At the same time, in the extrapulmonary TB group, significantly elevated PCT level was found in comparison to the non-active pulmonary TB group and healthy controls (P＜0. 05＝. ROC analysis revealed that optimal discrimination between the active pulmonary TB and the other TB disease could be performed at a suggested cut-off point of 0. 15 ng/mL, with a sensitivity of 76. 9% and specificity of 81. 2%. After effective treatment, level of PCT in the active pulmonary TB group was decreased significantly. It is suggested that PCT might have diagnostic and prognostic value in the active pulmonary TB infection.关键词
结核分枝杆菌/活动性肺结核/降钙素原Key words
Mycobacterium tuberculosis / active pulmonary tuberculosis/ procalcitonin分类
医药卫生引用本文复制引用
伊正君,裴景亮,李瑞芳,付玉荣..降钙素原在结核病诊断的价值[J].中国人兽共患病学报,2012,28(8):792-794,3.基金项目
国家自然科学基金项目(No.30972639)和山东省高等学校科技计划项目(No.J09LF20)联合资助 （No.30972639）
