中国人兽共患病学报2012，Vol.28Issue(10)：1020-1024,5.DOI:10.3969/cjz.j.issn.1002-2694.2012.10.013
寄生虫感染对树突状细胞亚群的影响
Parasitic infection to dendritic cell subsets
摘要
Abstract
Dendritic cells (DCs) are most currently known as a class of professional antigen presenting cells in body, and also are initiators in the primary immune response by strongly activating naive T cells. DCs determine the direction of immune response, in parasitic infection,DCs are heterogeneous cell population. With the changing of physical and chemical environment around DC, the DCs may differentiate into different subsets in their growth and development process. The biological character istics of different DC subsets are quite different. A wide variety of parasites can cause serious harm to host and make complex and changeable mechanism in parasites. The major categories of parasites are protozoa(,Plasjnodium, Leishmania, Tozoplasma gondii) and helminth (Schistosoma, Clonorchis sinensis , Echinococcosis). DCs play an important role in the immune response against the parasitic infection in the host. After the parasite infection, on the one hand, parasites mainly affect DC maturation in host and induce Thl type responses, so this process is conducive to the host anti infection; on the other hand, parasites mainly suppress the normal function of the DC and reduce the body resistance, so it is benefit to parasite growth in body and cause great harm to the host. In recent years, the study about different types of parasitic infection to dendritic cell subsets also fur ther continue. This article provides a review about the source,and the main function and role of the DC subsets in parasite infec tion immunity.关键词
树突状细胞亚群/寄生虫感染/T细胞Key words
dendritic cell subsets/parasitic infection/T cells分类
医药卫生引用本文复制引用
刘晓霞,朱明,徐琦,丁剑冰..寄生虫感染对树突状细胞亚群的影响[J].中国人兽共患病学报,2012,28(10):1020-1024,5.基金项目
国家自然科学基金项目(No.81060135,No.81160378,No.30860263)和包虫病重点实验室开放课题(XJDX0202-2010-04)资助 （No.81060135,No.81160378,No.30860263）
