首页|期刊导航|中国神经再生研究（英文版）|Expression of Clock genes in the pineal glands of newborn rats with hypoxic-ischemic encephalopathy

Expression of Clock genes in the pineal glands of newborn rats with hypoxic-ischemic encephalopathy

Bin Sun Xing Feng Xin Ding Li Bao Yongfu Li Jun He Meifang Jin

中国神经再生研究（英文版）2012，Vol.7Issue(28)：2221-2226,6.

中国神经再生研究（英文版）2012，Vol.7Issue(28)：2221-2226,6.DOI:10.3969/j.issn.1673-5374.2012.028.008

Expression of Clock genes in the pineal glands of newborn rats with hypoxic-ischemic encephalopathy

Bin Sun ¹Xing Feng ¹Xin Ding ¹Li Bao ²Yongfu Li ³Jun He ⁴Meifang Jin¹

作者信息

1. Division of Neonatology, Affiliated Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China
2. Department of General Pediatrics, Yixing People's Hospital, Yixing 214200, Jiangsu Province, China
3. Division of Neonatology, Suzhou Municipal Hospital(Main Campus), Suzhou 215002, Jiangsu Province, China
4. Jiangsu Institute of Hematology and Blood Diseases, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
折叠

摘要

Abstract

Clock genes are involved in circadian rhythm regulation,and surviving newborns with hypoxic-ischemic encephalopathy may present with sleep-wake cycle reversal.This study aimed to determine the expression of the clock genes Clock and Bmall,in the pineal gland of rats with hypoxic-ischemic brain damage.Results showed that levels of Clock mRNA were not significantly changed within 48 hours after cerebral hypoxia and ischemia.Expression levels of CLOCK and BMAL1 protein were significantly higher after 48 hours.The levels of Bmall mRNA reached a peak at 36 hours,but were significantly reduced at 48 hours.Experimental findings indicate that Clock and Bmall genes were indeed expressed in the pineal glands of neonatal rats.At the initial stage (within 36 hours) of hypoxic-ischemic brain damage,only slight changes in the expression levels of these two genes were detected,followed by significant changes at 36 48 hours.These changes may be associated with circadian rhythm disorder induced by hypoxic-ischemic brain damage.

关键词

brain hypoxia/ cerebral ischemia/ neonatal rats/ pineal gland/ Clock/ Bmal1/ mRNA/ protein/ brain/ neural regeneration

Key words

brain hypoxia/ cerebral ischemia/ neonatal rats/ pineal gland/ Clock/ Bmal1/ mRNA/ protein/ brain/ neural regeneration

引用本文复制引用

Bin Sun,Xing Feng,Xin Ding,Li Bao,Yongfu Li,Jun He,Meifang Jin..Expression of Clock genes in the pineal glands of newborn rats with hypoxic-ischemic encephalopathy[J].中国神经再生研究（英文版）,2012,7(28):2221-2226,6.

基金项目

This study was supported by grants from the Foundation for Advancing Medical Sciences of the Health Department,Jiangsu Province,No.Z200519,and the Project for Social Development of Suzhou,No.SSZ0230. （）

中国神经再生研究（英文版）

OACSCDCSTPCDSCI

ISSN：1673-5374

访问量0

下载量0

段落导航