首页|期刊导航|中国神经再生研究（英文版）|Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling
中国神经再生研究（英文版）2012，Vol.7Issue(32)：2485-2491,7.DOI:10.3969/j.issn.1673-5374.2012.32.001
Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling
Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling
摘要
Abstract
Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway.关键词
retinoic acid/neural tube defects/myeloid tissues/caspase-3/apoptotic kinase/c-Jun N-terminal kinase/mitogen-activated protein kinase/neural development/regeneration/neural regenerationKey words
retinoic acid/neural tube defects/myeloid tissues/caspase-3/apoptotic kinase/c-Jun N-terminal kinase/mitogen-activated protein kinase/neural development/regeneration/neural regeneration引用本文复制引用
Yinghuan Ma,Yongxin Bao,Chenghao Li,Fubin Jiao,Hongjie Xin,Zhengwei Yuan..Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling[J].中国神经再生研究（英文版）,2012,7(32):2485-2491,7.基金项目
This project was supported by the National Natural Science Foundation of China,No.30872705/HD426 and No.81070538/HD429. （）
