首页|期刊导航|中国神经再生研究（英文版）|Morphological differences in skeletal muscle atrophy of rats with motor nerve and/or sensory nerve injury

Morphological differences in skeletal muscle atrophy of rats with motor nerve and/or sensory nerve injury

Lei Zhao Guangming Lv Shengyang Jiang Zhiqiang Yan Junming Sun Ling Wang Donglin Jiang

中国神经再生研究（英文版）2012，Vol.7Issue(32)：2507-2515,9.

中国神经再生研究（英文版）2012，Vol.7Issue(32)：2507-2515,9.DOI:10.3969/j.issn.1673-5374.2012.32.004

Morphological differences in skeletal muscle atrophy of rats with motor nerve and/or sensory nerve injury

Lei Zhao ¹Guangming Lv ²Shengyang Jiang ³Zhiqiang Yan ⁴Junming Sun ³Ling Wang ³Donglin Jiang³

作者信息

1. Department of Orthopedics,Third Affiliated Hospital of Nantong University,Wuxi 214041,Jiangsu Province,China
2. Key Laboratory of Neural Regeneration of Jiangsu Province,Nantong University,Nantong 223001,Jiangsu Province,China
3. Central Laboratory,Third Affiliated Hospital of Nantong University,Wuxi 214041,Jiangsu Province,China
4. Laboratory of Mechanical Biology and Medical Engineering,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China
折叠

摘要

Abstract

Skeletal muscle atrophy occurs after denervation. The present study dissected the rat left ventral root and dorsal root at L4-6 or the sciatic nerve to establish a model of simple motor nerve injury, sensory nerve injury or mixed nerve injury. Results showed that with prolonged denervation time, rats with simple motor nerve injury, sensory nerve injury or mixed nerve injury exhibited abnormal behavior, reduced wet weight of the left gastrocnemius muscle, decreased diameter and cross-sectional area and altered ultrastructure of muscle cells, as well as decreased cross-sectional area and increased gray scale of the gastrocnemius muscle motor end plate. Moreover, at the same time point, the pathological changes were most severe in mixed nerve injury, followed by simple motor nerve injury, and the changes in simple sensory nerve injury were the mildest. These findings indicate that normal skeletal muscle morphology is maintained by intact innervation. Motor nerve injury resulted in larger damage to skeletal muscle and more severe atrophy than sensory nerve injury. Thus, reconstruction of motor nerves should be considered first in the clinical treatment of skeletal muscle atrophy caused by denervation.

关键词

simple nerve injury/muscular atrophy/ultrastructure/motor end plate/rats/neural regeneration

Key words

simple nerve injury/muscular atrophy/ultrastructure/motor end plate/rats/neural regeneration

引用本文复制引用

Lei Zhao,Guangming Lv,Shengyang Jiang,Zhiqiang Yan,Junming Sun,Ling Wang,Donglin Jiang..Morphological differences in skeletal muscle atrophy of rats with motor nerve and/or sensory nerve injury[J].中国神经再生研究（英文版）,2012,7(32):2507-2515,9.

基金项目

This study was supported by Clinical Scientific Research Foundation of Nantong University,No.200626. （）

中国神经再生研究（英文版）

OACSCDCSTPCDSCI

ISSN：1673-5374

访问量0

下载量0

段落导航