中国比较医学杂志2012，Vol.22Issue(10)：23-26,4.DOI:10.3969.j.issn.1671.7856.2012.010.006
不同造模剂诱导大鼠高尿酸血症模型的可行性比较
Comparison of the Feasibilities of Different Inducing Agents in the Establishment of Rat Models of Hyperuricemia
摘要
Abstract
Objective To eompare three rat models of hyperurieemia indueed by different agents. Methods Twenty healthy male adult (SPF) Sprague-Dowley rats were randomly distributed into three model groups and eontrol group. Rats in the model groups received 5% oionate diet (5% OA) , 10％ yeast extract diet (10％YE) , 10％ yeast extract + 2％ oxonate diet (10％ YE +2％0A) , respectively, for three weeks, and then normal diet for one week. The control group received normal diet. Blood and urine samples were assayed to determine the levels of uric acid, creatinine , nitrogen, albumin, triglyceride and cholesterol. Results Compared with the control group, serum uric acid levels in the 5% OA group were significantly higher and consistently ( P < 0. 05 ) . The serum uric acid levels in the 10% YE group increased only in the second week (P<0.05) . In the 10％ YE + 2％ OA group, serum uric acid levels increased in the first and second weeks (P < 0. 05) , then decreased. There were no significant differences in the serum creatinine, nitrogen, albumin and body weight among the four groups (P > 0. 05 ) . Conclusions The rat model of hyperuricemia induced by 5％ OA is stable and enduring. The 10％ YE models hardly reach hyperuricemia status. The 10％ YE + 2％ OA models have unstable high level of serum uric acid.关键词
氧嗪酸钾/酵母粉/高尿酸血症/动物模型/大鼠Key words
Potassium oxonate / Yeast extract/ Hyperuricemia/ Animal models/ Rat分类
医药卫生引用本文复制引用
周道远,陈敏,刘岩..不同造模剂诱导大鼠高尿酸血症模型的可行性比较[J].中国比较医学杂志,2012,22(10):23-26,4.基金项目
广州市科技计划项目(2009J1-C331) （2009J1-C331）
广东省自然基金项目(S2011010005565). （S2011010005565）
