中国比较医学杂志2012，Vol.22Issue(10)：67-71,5.DOI:10.3969.j.issn.1671.7856.2012.010.016
兴奋性氨基酸转运体2在神经退行性变中的作用
Role of EAAT2 in Neurodegenerative Diseases
摘要
Abstract
Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory amino acid transporter ( EAAT) -2 is one of the major glutamate transporters expressed predominantly in astroglial cells and is responsible for 90% of total glutamate uptake. Glutamate transporters tightly regulate glutamate concentration in the synaptic cleft. Dysfunction of EAAT2 and accumulation of excessive extracellular glutamate has been implicated in the development of several neurodegenerative diseases including Alzheimer' s disease , Huntington' s disease , and amyotrophic lateral sclerosis. Analysis of the human EAAT2 promoter showed that NF-kB is an important regulator of EAAT2 expression in astrocytes. Screening of approximately 1 , 040 FDA-approved compounds led to the discovery that many b-lactam antibiotics such as ceftriaxone etc. are transcriptional activators of EAAT2 resulting in increased EAAT2 protein levels and produce neuroprotective effects.关键词
谷氨酸/兴奋性氨基酸转运体2/神经退行性变/NF-kB/头孢曲松钠Key words
Glutamate /Excitatory amino acid transporter-2 / Neurodegenerative disesases / NF-kB/ Ceftriaxone分类
医药卫生引用本文复制引用
许保磊,王蓉..兴奋性氨基酸转运体2在神经退行性变中的作用[J].中国比较医学杂志,2012,22(10):67-71,5.基金项目
北京市自然科学基金(编号:7082043) （编号:7082043）
首都卫生发展科研专项项目(编号:2011-1001-02) （编号:2011-1001-02）
北京市卫生系统高层次卫生技术人才计划资助项目(编号:2009-3-64). （编号:2009-3-64）
