中国比较医学杂志2012，Vol.22Issue(11)：63-67,5.DOI:10.3969.j.issn.1671.7856.2012.011.014
α-synuclein致病机制和转基因帕金森疾病模型研究进展
The Advances in α-synuclein Toxic Mechanisms and Transgenic Models of Parkinson Disease
摘要
Abstract
α-synuclein, a presynaptic protein , was found to be the major component of the lewy bodies in inherited and sporadic Parkinson's disease(PD). α-synuclein point mutations or genetic alteration can cause Parkinson 's disease ( PD). It is thought to be involved in the processes of neurodegeneration . This paper reviewed the toxic mechanisms of α-\ synuclein in Parkinson disease and α-synuclein transgenic animal models.关键词
α-突触核蛋白/帕金森/疾病模型/转基因Key words
α-synuclein/Parkson disease/Disease models/Transgenic分类
医药卫生引用本文复制引用
张丽,张连峰..α-synuclein致病机制和转基因帕金森疾病模型研究进展[J].中国比较医学杂志,2012,22(11):63-67,5.基金项目
国家科技支撑计划课题(2012BA139B02) （2012BA139B02）
国家"重大新药创制"科技重大专项课题(2011ZX09307-302). （2011ZX09307-302）
