中国实用儿科杂志2012，Vol.27Issue(9)：671-674,4.
幽门螺杆菌感染与儿童慢性胃炎胃黏膜病理变化关系研究
Relationship between pathological change of gastric mucosa in children with chronic gastritis and Helicobacter pylori infection
摘要
Abstract
Objective To investigate the correlation between the Helicobacter pylori (HP) infection in children with chronic gastritis of different age and the pathologic change of their gastric mucosa. Methods Electronic gastroscope examinations were performed in 1634 children who came to Ruijin Hospital, Shanghai Jiaotong University School of Medicine for repeated upper gastrointestinal symptoms from January 2007 to December 2010. Then the antral mucosal tissues were extracted for the. HP detection and pathologic analysis. The histopathologieal findings were scored and classified according to the Sydney System. Correlations between the inflammatory severity and HP infection were discussed. The detection rate of HP infection,active inflammation and lymphoid follicle were compared among the four different groups divided according to age. Results Totally 524 (32.1%) patients showed HP positive,and the positive rate increased with age. The detection rates of active pathological change, severe inflammation, polymorphonuclear leukocyte infiltration, severe lymphocyte infiltration and lymphoid follicle were all higher in HP-positive group than in the control. The proportions of the midrange to severe chronic superficial gastritis and the midrange chronic atrophic gastritis were higher in HP-positive group than in the control. The detection rates of active inflammation and lymphoid follicles were significantly higher in all age groups of children with HP infection than in HP negative patients. Conclusion The infection rate of HP in children increases with age. HP infection is positively correlated with the severity of the gastric mucosal inflammation, the incidence of the active pathological change and lymphoid follicle.关键词
幽门螺杆菌/儿童/慢性胃炎/胃黏膜/病理Key words
Helicobacter pylori, HP/ children/ chronic gastritis/ gastric mucosa/ pathology分类
医药卫生引用本文复制引用
余熠,张寅,王筱金,许春娣..幽门螺杆菌感染与儿童慢性胃炎胃黏膜病理变化关系研究[J].中国实用儿科杂志,2012,27(9):671-674,4.基金项目
国家自然科学基金资助项目(No.81000163 （）
No.81170363) （）
上海市科委重点研究项目(No.09JC1409900) （No.09JC1409900）
