中国实用妇科与产科杂志2012，Vol.28Issue(9)：685-687,3.
宫颈鳞癌组织中TPX2的表达及其临床意义
Expression of TPX2 in cervical squamous carcinoma and clinical significance
常海平 1王敬芝 1田原 1徐杰 1勾晓娟 1程建新1
作者信息
- 1. 河北医科大学第四医院妇产科,河北石家庄050011
- 折叠
摘要
Abstract
Objective To study the expression of TPX2 protein and mRNA in human cervical squamous carcinoma, and the relationship between its expression and clinicopathologyical features of cervical cancer. Methods Between October 2009 and November 2010 in the Fourth Hospital of Hebei Medical University, Immunohistochemistry and reverse transcription polymerase chain reaction were used to analyze the expression levels of TPX2 mRNA and protein respectively, in fresh invasive cervical squamous cancer (n =62) 、normal cervical uteri (n = 15) and CIN tissues (re =30). Results By RT-PCR, there was no expression of TPX2 mRNA in normal cervical tissues, The expression of TPX2 mRNA cervical carcinoma is 0. 441 ± 0. 011, respectively. There was significant difference among the two tissues (t = - 19. 568 ,P < 0. 01). By immunohistochemistry, normal cervical tissues did not express TPX2. The expression of TPX2 in CIN and cervical carcinoma were increased respectively, There was significant difference among the three tissues ( P < 0. 05 ) . The expression of TPX2 were correlated with histologicalgrade、 FIGO stages、and lymph nodemetastasis (P < 0. 05 ) and not correlated with age ( P > 0. 05 ). Conclusion TPX2 is probably involved in early carcinogenesis of cervical squamous carcinoma. The detection of TPX2 expression may play an important role in early diagnosis and evaluation of prognosis in patients with cervical squamous carcinoma.关键词
宫颈肿瘤/TPX2/逆转录聚合酶链式反应/免疫组织化学Key words
cervical cancer/ TPX2/ RT-PCR/ immunohistochemistry分类
医药卫生引用本文复制引用
常海平,王敬芝,田原,徐杰,勾晓娟,程建新..宫颈鳞癌组织中TPX2的表达及其临床意义[J].中国实用妇科与产科杂志,2012,28(9):685-687,3.
