中国实用外科杂志2012，Vol.32Issue(11)：942-944,3.
乳腺癌组织中DCC MMP-9蛋白表达与影像学特征关系探讨
Correlation of DCC and MMP-9 expression with the ultrasonic appearance in breast cancer
摘要
Abstract
Objective To investigate the correlation of DCC and MMP-9 expression with the ultrasonic appearance in breast cancer. Methods Seventy samples of breast cancer and surrounding non-tumour breast tissues were resected between June 2010 and April 2011 in the Department of Breast Surgery, the People' s Hospital of Henan Province. Expression of DCC and MMP-9 was examined using immunohistochemistry technique. The results were compared with the ultrasonic features of breast cancer. MDI of breast infiltrating ductal carcinoma and breast fibroma was measured. Results The frequency of DCC expression was 82.9% for morphological normal breast tissue and 38.6% for breast cancer respectively (P<0.05). The frequency of MMP-9 expression was 17.1% for morphological normal breast tissue and 78.6% for breast cancer respectively (P<0.05). DCC and MMP-9 expression correlated with breast cancer invasion and metastasis in ultrasonography. There was significant difference between the MDI of DCC/MMP-9 positive expression and negative expression (P<0.05). Conclusion Expression of DCC and MMP-9 may play some roles in occurrence, development and metastasis of breast cancer. Combination of DCC, MMP-9 expression and ultrasonic appearance can be effective to predict the prognosis of breast cancer.关键词
结直肠癌缺陷基因/基质金属蛋白酶-9/乳腺癌/微血管密度Key words
deleted in colorectal cancer gene/matrix metallopeptidase 9/breast cancer/microvascular density分类
医药卫生引用本文复制引用
李文涛,吴刚,支慧,丁超,贾林娇,翟保平..乳腺癌组织中DCC MMP-9蛋白表达与影像学特征关系探讨[J].中国实用外科杂志,2012,32(11):942-944,3.基金项目
河南省2010年科技发展计划项目(02300410133) （02300410133）
