摘要
Abstract
OBJECTIVE: To observe the effect of the level of bere metabolism with methotrexate combined with 99Tc-MDP and vitamin D in the treatment of ankylosing spondylitis (AS). METHODS: 60 AS patients were randomly divided into 2 groups. 2 groups were given methotrexate 10-15 mg weekly, vitamin D calcium (each containing calcium element 300 mg, vitamin D 100 U) , qd, 2 pieces. On this basis, the treatment group was additionally given technetium 99TC-MDP 10 mg dissolved in 0.9% Sodium chloride injection 250 mL via intravenous infusion, qd, for 10 d. Next treatment course continued 30 d after, with a total of 6 courses. The bone mineral density (BMD), levels of bone-specific alkaline phosphatase (BALP), 25-(OH) D3, vitamin D receptor (VDR), erythrocyte sedimentation in the peripheral blood and other indicators were observed in 2 groups before and after treatment, and the therapeutic efficacy of the patients was evaluated using AS disease activity index (BASDAI). RESULTS: The normal BMD of patients in 2 groups after treatment were higher than before treatment, and there was statistical significance in the difference between groups or treatment group before and after treatment (P<0.05); the levels of BALP, 25-(OH) D3, VDR, erythrocyte sedimentation in 2 groups after treatment were significantly higher than before treatment, there was statistical significance in the difference between 2 groups, except VDR (P<0.05). There was no serious ADR found in 2 groups. CONCLUSION: On the basis of methotrexate combined with vitamin D therapy, addition of 99Tc-MDP obtain optimal therapeutic efficacy in the treatment of ankylosing spondylitis.关键词
强直性脊柱炎/骨代谢/25-(OH)D3/维生素D受体Key words
Ankylosing spondylitis/ Bone metabolism/ 25-(OH)D3/ Vitamin D receptor分类
医药卫生
