中国药房2012，Vol.23Issue(35)：3268-3270,3.DOI:10.6039/j.issn.1001-0408.2012.35.02
鲜壁虎醇提物与水提物体内、外对肿瘤活性的影响
Effects on Tumor Activity of Aqueous and Ethanol Extracts from Gekko swinhonis Gunther
摘要
Abstract
OBJECTIVE: To study the in vitro and in vivo antitumor activity of the aqueous and ethanol extracts from Gekko swinhonis Gunther. METHODS: The inhibitory effects of aqueous and ethanol extracts from G. swinhonis on proliferation of BEL-7402 cell and Hep G2 cell in vitro were measured by MTT assay. The in vivo H22 tumor mice model was induced to calculate anti-tumor rate, thymus gland index and spleen index. RESULTS: The aqueous extracts of G. swinhonis Guther 0.062 5 mg-mL-1 inhibited the proliferation of Hep G2 cells. The aqueous extracts of G. swinhonis Guther 1.000 0,0.250 0,0.062 5 mg-mL-1 inhibited the proliferation of BEL-7402 cells. The water extracts from G. swinhonis Guther 1.000 0,0.250 0,0.062 5 mg·mL-1 and the ethanol extracts from G. swinhonis Guther 1.000 0,0.062 5 mg·mL-1 promoted the proliferation of 2 kinds of cells. The ethanol extracts from G. swinhonis Guther 1.000 0,0.250 0,0.062 5 mg·mL-1 inhibited the activity of tumor in H22 hepatocarcinoma-bearing mice. CONCLUSION: The agueeus extracts of G. swinhonis Guther can inhibit the growth of tumor cell in vitro, while ethanol extract of it promote the proliferation of tumor cell. They all have antitumor effect, but the in vivo antitumor effects of aqueous extracts of G. swinhonis Guther is more effective than ethanol extracts.关键词
壁虎/抗肿瘤/Hep G2细胞/BEL-7402细胞/H22细胞Key words
Gekko swinhonis Gunther/ Anti-tumor/ Hep G2 cell/ BEL-7402 cell/ H22 cell分类
医药卫生引用本文复制引用
赓迪,孙华颖,王春梅..鲜壁虎醇提物与水提物体内、外对肿瘤活性的影响[J].中国药房,2012,23(35):3268-3270,3.基金项目
教育部留学回国人员科研启动基金 （）
北京中医药大学自主课题 （）
