中国药房2012，Vol.23Issue(36)：3419-3420,2.DOI:10.6039/j.issn.1001-0408.2012.36.23
瑞舒伐他汀与辛伐他汀对脑梗死患者颈动脉粥样斑块的影响
Effects of Rosuvastatin vs. Simvastatin on Carotid Atherosclerotic Plaque in Patients with Cerebral Infarction
黄胜立1
作者信息
- 1. 南京军区福州总医院九五临床部,福建莆田351100
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the effects of rosuvastatin and simvastatin on carotid atherosclerotic plaques in patients with cerebral infarction. METHODS: 100 cerebral infarction inpatients with carotid atherosclerotic plaques were collected from our hospital, and they were randomized into treatment group and control group. On the basis of regular foundation treatment for cerebral infarction, 50 cases in treatment group were additionally given rosuvastatin orally, and other 50 cases in control group given simvastatin orally. 6 months later, change of blood lipid was evaluated and carotid atherosclerosis plaques intima-media thickness (IMT) was observed by carotid ultrasound review. RESULTS: Total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) of 2 groups were decreased, and there was no statistical significance in TG of control group before and after treatment (P＞0.05). The decrease of carotid plaques thickness in treatment group was more obvious than in control group, there was statistical significance (P＜0.05). CONCLUSION: Rosuvastatin is effective in the treatment of carotid atherosclerotic plaques in patients with cerebral infarction, and it is worthy of spreading in the clinic.关键词
瑞舒伐他汀/辛伐他汀/脑梗死/颈动脉粥样斑块Key words
Rosuvastatin/ Simvastatin/ Cerebral infarction/ Carotid atherosclerotic plaques分类
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黄胜立..瑞舒伐他汀与辛伐他汀对脑梗死患者颈动脉粥样斑块的影响[J].中国药房,2012,23(36):3419-3420,2.
