摘要
Abstract
OBJECTIVE: To evaluate the therapeutic efficacy of itraconazole agansit invasive fungal infection (IFI) in hematology patients underwent chemotherapy or hematopoietic stem cell transplantation (HSCT). METHODS: Retrieved from Cochrane library, Medline, EMbase, PubMed, CBM Database, CNKI, VIP database and Wanfang database and manual retrieval, related proceedings were collected. The Meta-analysis was performed by Rev Man 5.1 software. RESULTS: 14 literatures were included, involving 4 020 patients. Results of Meta-analysis indicated that the incidence of fungal infection in itraconazole group was lower than that of fluconazole group [OR=0.72, 95%CI(0.54, 0.96), P=0.02; OR=0.60, 95%CI(0.39, 0.93) , P=0.02] and higher than that of posaconazole [OR=4.90, 95%CI (1.58,15.15), P=0.006; OR=14.25, 95%CI (2.69,75.34), P=0.002], but there was no statistical significance, compared with amphotericin B group, caspofungin group and voriconazole group. There was no statistical significance in the difference of overall mortality and infection rate of Candidiasis spp. between itraconazole group and control group. CONCLUSION: The therapeutic efficacy of itraconazole against invasive fungal infection in hematology patients underwent chemotherapy and HSCT is better than fluconazole and worse than posaconazole, and equivalent with amphotericin B, caspofungin, voriconazole.关键词
伊曲康唑/侵袭性真菌感染/随机对照试验/荟萃分析Key words
Itraconazole/ Invasive fungal infection/ Randomized controlled trials/ Meta-analysis分类
医药卫生
