中国医科大学学报2012，Vol.41Issue(7)：599-602,4.
小鼠后肾发育中的细胞凋亡及凋亡小体行踪的超微结构
Apoptosis and The Ultrastructures of Apoptotic Bodies during Metanephric Development in Mice
摘要
Abstract
Objective To observe apoptotic bodies during metanephric development in mice. Methods light microscopy and electron microscopy were used to detect programmed cell death in mouse kidney of embryonic day 12,14,16,and 18. Results Programmed cell death was composed of apoptosis and necroptosis programmed death during the metanephric development, and apoptosis was the main process of programmed cell death. Apoptotic body consisted of shrinkage cytoplasm and pieces of pyknotic nucleus. Each type of metanephric cells had strong ability of phagocytosis. Apoptotic corpses were disposed by metanephric cells through phagocytosis. Phagocytosed apoptotic bodies were often observed and they were varied in number and in size when engulfed by neighbouring cells. Conclusion Apoptotic cells were engulfed mainly by autologous cells during metanephric development, and metanephric cells had strong ability of phagocytosis.关键词
后肾/凋亡小体/超微结构/发育/小鼠Key words
metanephros/apoptotic body/ultrastructure/development/mice分类
医药卫生引用本文复制引用
邵姝元,刘玉玲,郭敏,李晓明..小鼠后肾发育中的细胞凋亡及凋亡小体行踪的超微结构[J].中国医科大学学报,2012,41(7):599-602,4.基金项目
辽宁省教育厅高校科研计划(L2010269) （L2010269）
