中国医科大学学报2012，Vol.41Issue(7)：607-610,614,5.
胸腺五肽治疗大鼠扩张型心肌病的实验研究
The Treatment of Thymopentin in Rats with Dilated Cardiomyopathy
摘要
Abstract
Objective To investigate the effect of thymopentin on the treatment of left ventricular remodeling and cardiac function in rats with dilated cardiomyopathy (DCM ), and on the regulation to CD4, CD8, CD4/CD8, IFN-7 and IL-10 in serum. Methods A total of 45 6-week-old male Lewis rats were divided into three groups, 15 of which served as normal controls,30 were subcutaneously injected with cardiac myosin by hind foot pad to induce DCM. After immunization, they were randomly divided into thymopentin treatment group and saline treatment group. The medical treatment continued for 28 d. Echocardiography, hemodynamics and myocardial histopathological examination were performed; serum cytokines were examined by ELISA assay; flow cytometry was applied to examine T-lymphocyte subsets. Results LVIDd.LVISd were significantly reduced in thymopentin treatment group of DCM rats; IVSd and LVPWd were obviously thickened,EF was significantly increased; left ventricular minor axis and left ventricular cross-section diameter was markedly reduced; the ratio of heart weight to body weight,and LVEDP were significantly reduced,and MBP was clearly increased; lower level of serum IFN-7 and higher level of serum IL-10 were detected; the level of CD4 and the ratio of CD4 to CD8 were significantly reduced,the level of CD8 was evidently increased. Conclusion In the present study, thymopentin inhibited cardiac remodeling and improved heart function in rats with DCM. The results also suggested that thymopentin probably regulated the immune imbalance of rats with DCM by increasing the level of IL-10,reducing the level of IFN-7,and adjusting the ratio of CD4 to CD8.关键词
胸腺五肽/扩张型心肌病/T淋巴细胞亚群Key words
thymopentin/dilated cardiomyopathy/T-lymphocyte subsets分类
医药卫生引用本文复制引用
李鹏,贾志梅,马春燕,谢成耀,刘军,贾志军..胸腺五肽治疗大鼠扩张型心肌病的实验研究[J].中国医科大学学报,2012,41(7):607-610,614,5.基金项目
辽宁省教育厅高校科研计划(2009A740) （2009A740）
