中国医科大学学报2012，Vol.41Issue(8)：730-733,4.
TNF-α基因rs1800629位点多态性与汉族人群子宫颈癌发生风险无关
TNF-α rs1800629 Polymorphism is Unrelated to HPV16 Infection or Cervical Cancer Risk in Chinese Population
摘要
Abstract
Objective To investigate the relationship between TNF-α rs 1800629 polymorphism and the risk of HPV16 infection, cervical cancer or cervical cancer after HPV16 infection. Methods Totally 679 Chinese women were involved in this study and divided into three groups,including 204 HPV16 positive cervical cancer patients, 157 HPV16 positive normal cases and 318 HPV negative normal controls. All the samples were genotyped by PCR-RLFP. Results No significant difference was found of the allele and genotype distributions of TNF-α rsl800629 polymorphism between each two group (P > 0.05). There was no correlation between rsl800629 polymorphism and the risk of HPV16 infection (OR =0.581,95% CI:0.211-1.598,P=0.293),cervical cancer (OR =1.063,95% CI:0.371-3.041 ,P =0.910),or cervical cancer after HPV16 infection (OR =0.631,95% CI: 0.206-1.929, P =0.419). Conclusion Our results demonstrated that there was no association between TNF-α rsl800629 polymorphism and the risk of HPV16 infection,cervical cancer or cervical cancer risk after HPV16 infection.关键词
TNF-α/单核苷酸多态性/子宫颈癌/HPVKey words
TNF-α/ TNF-α rsl800629 polymorphism/ cervical cancer/ HPV分类
医药卫生引用本文复制引用
王宁,戴淑艳,张扬,张淑兰,王诗卓,张乔,魏恒,李威,银铎,鲁艳明..TNF-α基因rs1800629位点多态性与汉族人群子宫颈癌发生风险无关[J].中国医科大学学报,2012,41(8):730-733,4.基金项目
国家自然科学基金资助项目(30973191) （30973191）
辽宁省科学技术计划重大重点项目(2008225004) （2008225004）
辽宁省医学高峰建设工程(2010696) （2010696）
沈阳市社会发展科技攻关专项(F11-262-9-15) （F11-262-9-15）
中国医科大学附属盛京医院"盛京自由研究者"计划(200806) （200806）
