中国医科大学学报2012，Vol.41Issue(8)：734-737,4.
2型糖尿病患者胰岛素抵抗与合并周围神经病变的相关性分析
The Relationship between Insulin Resistance and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To investigate the relationship between insulin resistance and peripheral neuropathy in type 2 diabetes mellitus. Methods A total of 152 patients with type 2 diabetes were recruited into our retrospective control study and were divided into diabetic peripheral neuropathy (DPN) group (95 cases) and non-diabetic peripheral neuropathy (NDPN) group (57 cases). Differences of clinical indexes between the two groups such as blood glucose,serum insulin level,and degree of insulin resistance were compared. SPSS 18.0 software was used for statistical analysis. Results Compared with patients in NDPN group, patients in DPN group were older (55.15+1.17 vs 50.18±1.54 years old,P < 0.05),with longer diabetic duration (8.35±0.76 vs 5.44±0.67 years.P < 0.05),lower OGTT2h insulin level (36.12±3.19 vs 44.93±4.70 pmol/L,P < 0.05),higher HOMA-IR(5.48±0.52 vs 4.54±0.33,P> 0.05) and higher Matsuda index (2.44+ 0.22 vs 1.95±0.09,P< 0.05). Logistic regression showed that age,fasting blood glucose,fasting insulin levels and Matsuda index were independent risk factors of DPN in type 2 diabetes. Conclusion Fasting insulin resistance is the risk factor of DPN in type 2 diabetes, while post-prandial insulin resistance is preventable for DPN.关键词
胰岛素抵抗/2型糖尿病/糖尿病周围神经病变Key words
insulin resistance/ type 2 diabetes mellitus/ diabetic peripheral neuropathy分类
医药卫生引用本文复制引用
崔黎黎,赵传胜..2型糖尿病患者胰岛素抵抗与合并周围神经病变的相关性分析[J].中国医科大学学报,2012,41(8):734-737,4.基金项目
国家自然科学基金资助项目(30500611) （30500611）
