中国医科大学学报2012，Vol.41Issue(10)：915-920,6.
急性冠脉综合征经皮冠状动脉介入术中不同给药途径应用替罗非班的疗效与安全性的meta分析
Meta-analysis of Curative Efficacy and Safety of Tirofiban during Percutaneous Coronary Intervention for Acute Coronary Syndrome
摘要
Abstract
Objective To evaluate the curative efficacy and safety of tirofiban intraeoronary versus intravenous administration during percutaneous coronary intervention for patients with acute coronary syndrome in China. Methods Randomized controlled trials (RCT) comparing the effects of IV administration of tirofiban to those of IC administration between January 2006 and January 2012 in Chinese population were systematically searched. Fixed-effect or random-effect models were used, which accounts for within-study and between-study variability, to estimate pooled RR or WMD with their 95% CI. Results Totally 16 RCT were selected in this study,which involved 1 314 patients. Compared with subjects with IV administration, those with IC administration were more likely to reach TIMI grade 3 flow {RR = 1.13 ,95% CI [ 1.05 , 1.23 ], P < 0.01) and TMP grade 3 {RR=1.28,95% CI I 1.12,1.46] ,P =0.0002) ;more LVEF was observed (WMD=2.33% ,95% CI [0.88% ,3.78% ] ,P =0.002) but without clinical significance;no significant difference was observed in the frequency of short-term bleeding events{RR=0.99,95% CI[0.76,1.30],P =0.96) and thromlxx:ytopenia(RR=0.79,95% CI[0.42,1.51 ],P =0.48). Conclusion Compared with IV administration, IC administration may improve the perfusion after PCI in ACS patients and do not increase the risk of bleeding and thrombocytopenia.关键词
冠状动脉疾病/经皮冠状动脉介入治疗/替罗非班/给药途径/meta分析Key words
coroary disease/percutaneous coronary intervention/tirofiban /administration route/meta analysis分类
医药卫生引用本文复制引用
胡文宇,赵奕楠,田文,孙英贤..急性冠脉综合征经皮冠状动脉介入术中不同给药途径应用替罗非班的疗效与安全性的meta分析[J].中国医科大学学报,2012,41(10):915-920,6.基金项目
国家重点基础研究发展计划前期专项项目(2010CB535003) （2010CB535003）
