中国药理学通报2012，Vol.28Issue(11)：1481-1486,6.DOI:10.3969/j.issn.1001-1978.2012.11.001
线粒体功能损伤与胰岛素抵抗
Mitochondrial dysfunction and insulin resistance
摘要
Abstract
Insulin resistance plays an important role in the patho-genesis of obesity, metabolic syndrome, type; 2 diabetes mellitii and complication, cardiometabolic syndrome. Recent years, accumulative studies show that mitochondrial dysfunction is related to insulin resistance. Glucose and lipid metabolism are largely dependent on mitochondria to generate energy in cells. Genetic factors, ROS, aging, and reduced mitochondrial biogenesis all contribute to mitochondrial dysfunction. These factors also contribute to insulin resistance in classic and nonclassic insulin target tissues. This review discusses the mechanisms of mitochondria! dysfunction related to the pat ho physiology of insulin resistance.关键词
胰岛素抵抗/线粒体功能损伤/2型糖尿病/生物合成/老化/氧化应激/解偶联蛋白Key words
insulin resistance/ mitochondria! dysfunction/T2DM/ biosynthesis/ aging/ ROS/ UCP分类
医药卫生引用本文复制引用
时丽丽,张莉,谭初兵,徐为人,杜冠华..线粒体功能损伤与胰岛素抵抗[J].中国药理学通报,2012,28(11):1481-1486,6.基金项目
国家自然科学基金资助项目(No 81102492) （No 81102492）
科技部国际合作项目(No 2009DFA32010) （No 2009DFA32010）
国家重大新药创制专项-天津药物研究院企业创新药物孵化基地建设(No 2011ZX09401-009) （No 2011ZX09401-009）
