中国药理学通报2012，Vol.28Issue(11)：1497-1499,3.DOI:10.3969/j.issn.1001-1978.2012.11.005
蛋白激酶C和磷脂酰肌醇4,5二磷酸之间相互调节作用的研究进展
Progress in the research of mutual regulation between PKC and PI(4,5)P2
摘要
Abstract
Protean kinase: C ( PKC ) comprises a multigeme family of related se:rine/threonine kinases that sit at the crossroads of many signed transeinetion pathways, playing an important reile with eomples funetieins. Phosphatieiylinositeil 4, 5-hisphosphate ( PIP, ) is a key signaling molecule in ceil membrane; it is not einly the precursor elf sellable inetsitetl phetsphate ( IP, ) anel dia-cylglyccrol ( DAG ), it can also ae-t as a sceonel messenge:r itscif. Phospheolipase C ( PLC ) hydrolyzes PIP2 to generate memhrane- hounel DAG, which aetivates PKC, and IP3 , which mobilizes in-traeellular caleinm to regulate the activity etf PKC. The ae'tivation of PKC ine-re:ase:s the aetivity of PI4 kinase or PIP5 kinase to en-hanee the synthesis of PIP,. This review ele:als with the mutual regulation hetween PKCs anel PIP, anel current progress in reiateel researeh.关键词
蛋白激酶C/磷脂酰肌醇(4/5)二磷酸(PIP2)/钙离子/磷脂酶C/(PLC)/信号转导/调节Key words
preitein kinase C/ PIP2 / Ca3+ , PLC/ signal trans-cluetion/ regulation分类
医药卫生引用本文复制引用
陈兴娟,张熙东,张璇,杲海霞,张海林..蛋白激酶C和磷脂酰肌醇4,5二磷酸之间相互调节作用的研究进展[J].中国药理学通报,2012,28(11):1497-1499,3.基金项目
国家自然科学基金重点项目(No 30730031) （No 30730031）
