中国药理学通报2012，Vol.28Issue(11)：1574-1578,5.DOI:10.3969/j.issn.1001-1978.2012.11.022
TCRP1在口腔鳞癌中介导顺铂耐药的体内实验研究
Effects of TCRP1 on mediating resistance to cisplatin in vivo in OSCC
摘要
Abstract
Aim TCRP1 is a novel gene which was cloned from a muki-drug rcsistant cell line Tca8113/ PYM in previous research. The preliminary functional investigation in vitro indicated that TCRP1 was a new ehemo-resisLanee related gene, which mediated specifically resisLanee to cisplatin in Oral Squamous Cell Carcinoma ( OSCC ) cells. This study aims to futher explore the offeel of TCRP1 in OSCC in vivo. Methods The eflect of TCRPlon sensitivity to cisplatin and 5-Fu was observed through establishing the ectopic tumor animal model of over/silence expression of TCRP1 , and then the initiatory mechanism was imvesLigated. Results The outcome of tumor growth curves and tumor weiglit displayed that TCRP1 significantly increased the resistanee to cisplatin in OSCC ectopic tumor, but not to 5-Fu. And the TUNEL assay indicated there were fewer number of apoptosis cells in up-regulated TCRP1 tumor tissue. Conclusion TCRP1 is a novel chemo-resistanee related gene, and its functional mechanism is correlated with reducing the cells apoptosis induced by cisplatin.关键词
肿瘤/口腔鳞癌/顺铂/耐药/TCRP1/体内实验/凋亡Key words
tumor/ OSCC/ cisplatin/ resistanee/ TCRP1 / experiment in vivo/ apoptosis分类
医药卫生引用本文复制引用
谷依学,范莎莎,王成昆,彭波,张为家,贺智敏..TCRP1在口腔鳞癌中介导顺铂耐药的体内实验研究[J].中国药理学通报,2012,28(11):1574-1578,5.基金项目
国家自然科学基金资助项目(No 30873088) （No 30873088）
教育部博士点基金资助项目(No 200805330009) （No 200805330009）
