中国药理学通报2012，Vol.28Issue(11)：1582-1585,4.DOI:10.3969/j.issn.1001-1978.2012.11.024
灰毡毛忍冬与忍冬的药理作用比较研究
Comparison of the pharmacological effects between L.macranthoides Hand.-Mazz and Lonicera japonica Thunb
摘要
Abstract
Aim To study the main pharmacological effects of L. macranthoides Hand. -Mazz and Lonicera japonica Thunb. Methods Through observing the an-tihactorial activkies on 6 kinds of hactoria in vitro, the antihacterial activitios of the two kinds of medicinal matorials wore compared. The anti-inflammatory offocts of them were comparod by modeling increase of blood capillary permeability with mice, swelling of foot and granuloma on tampon with rats; the immunological reg-ulation was detected by weighing the immune organs of low-immunity mice induced by injecting CTX, and the phagocylosis function of phagocylic cells in mice was researched. Results The antibacterial activkies of L. macranthoides Hand. -Mazz and Lonicera japonica Thunb were different on those 6 kinds of bacteria. M1C:7. 8~62.8 g · L-1 and 15.7~ 125 g · L-1 , MBC: ≥250 g · L-1 and ≥500 g · L-1. They could obviously reduce the blood capillary permeability increase of mice, the foot swelling degree of rats and the hyperplasia of granuloma of rats. In addkion, with the administration of them, the organ index, the clearance index K and the phagocylosis index a were increased. However, the effects of them showed no significant difference. Conclusions Both ( L. -macranthoide Hand. -Mazz) and tonicera japonica Thunb have antibacterial, anti-inflammatory and non-specific immunity func-tions. And these functions of them are almost equal.关键词
灰毡毛忍冬/忍冬/抗菌/抗炎/免疫调节/药理作用Key words
L. macranthoides Hand. -Mazz/ tonicera japonica Thunb/ antibacterial/ anti-inflammatory/ immunological regulation/ pharmacological effects分类
医药卫生引用本文复制引用
张小娜,唐清,侯敏,李烨,徐晓玉..灰毡毛忍冬与忍冬的药理作用比较研究[J].中国药理学通报,2012,28(11):1582-1585,4.基金项目
国家科技计划课题专项(No 2006BACD1A16) （No 2006BACD1A16）
重庆市"十一五"规划项目 （）
秀山县政府资助 （）
