中国药理学与毒理学杂志2012，Vol.26Issue(5)：680-683,4.DOI:10.3867/j.issn.1000-3002.2012.05.015
Epac/Rap1信号通路在急性肺损伤中作用的研究进展
Progress in role of Epac/Rap1 signal pathway in acute lung injury
摘要
Abstract
The loss control of the inflammatory signal pathway and the disorder balance of the inflammatory cytokines is an important cause of acute lung injury (ALI). The exehange protein activated by cAMP(Epac) is a new effector in the regulation of the pulmonary airway inflammation and cell proliferation. New research on cAMP-dependent but PKA-independent pathways indicates that cAMP/Epac/Rapl signal pathway is involved in the function of many cell types, including cell secretion, cell adhesion and connection, apoptosis, cell proliferation and differentiation. cAMP participates in the pathogenesis of ALI/ARDS through the Epac-Rapl signaling pathway that is a potential target for the control of ALI/ARDS. This article reviews domestic and foreign research progress of the mechanism of the Epac-Rapl signaling pathway in the lung-related inflammation and acute lung injury.关键词
急性肺损伤/鸟嘌呤核苷酸交换因子类/气道炎症/环磷酸腺苷Key words
acute lung injury/guanine nucleotide exchange factors/airway inflammation/cAMP分类
医药卫生引用本文复制引用
汪雪峰,陈思煜,陈锋..Epac/Rap1信号通路在急性肺损伤中作用的研究进展[J].中国药理学与毒理学杂志,2012,26(5):680-683,4.基金项目
国家自然科学基金资助项目(81202980) （81202980）
