中国药理学与毒理学杂志2012，Vol.26Issue(5)：702-705,4.DOI:10.3867/j.issn.1000-3002.2012.05.020
作用于不同靶点的抗乙型肝炎病毒天然药物的研究进展
Progress in anti-hepatitis B virus natural drugs targeting different sites
摘要
Abstract
Hepatitis B virus (HBV) is one of the acute pathogenic factors of severe hepatitis B and belongs to DNA viruses, with a strong ability of multiplication and typical process of virus infection. In recent years, medical and pharmaceutical researchers have paid moTe attention to investigating natural drugs with anti-HBV activities. These natural drugs have different mechanisms from nucleoside drugs. The targeting sites of natural anti-HBV products mainly focus on the promoters, hepatocyte nuclear factors combining with HBV promoters during HBV transcription, heat-shock cognate protein 70 which is required in the process of HBV nuclear capsid assembling, and alpha-glycosidase and important kinase ATM in the process of DNA damage and repair. Based on the biological characters and HBV infection process, this paper introduces the related natural medicine at different targets of HBV proliferation.关键词
肝炎病毒,乙型/天然产物/肝细胞核因子类/HSP70热激蛋白质类/α葡糖苷酶类Key words
hepatitis B virus/natural product/hepatocyte nuclear factors/HSP70 heat-shock proteins/alpha-glucosidases分类
医药卫生引用本文复制引用
李沿涛,许瑞安,崔秀灵..作用于不同靶点的抗乙型肝炎病毒天然药物的研究进展[J].中国药理学与毒理学杂志,2012,26(5):702-705,4.基金项目
福建省闽江学者支持计划(10BS216) （10BS216）
厦门市科技计划项目(3502z20101014) （3502z20101014）
华侨大学基本科研业务费专项基金(JB-GJ1008) （JB-GJ1008）
