中国医学科学院学报2012，Vol.34Issue(5)：509-514,6.DOI:10.3881/j.issn.1000-503X.2012.05.013
前列腺六次跨膜蛋白-2基因多态性与新疆维吾尔族人糖尿病的相关性
Genetic Polymorphism of Six Transmembrance Protein of Prostate 2 Associated with Diabetes Mellitus in Xinjiang Uygur Population
摘要
Abstract
Objective To investigate the association between the genetic variations of six transmembrance protein of prostate 2 (STAMP2) with type 2 diabetes mellitus (T2DM) in Xinjiang Uygur population. Methods A case-control study was conducted based on epidemiological investigation. A total of 1838 Uygur subjects were selected and divided into two groups: T2DM group ( n = 274) and control group ( n = 1564). All exons, flanking introns, and the promoter regions of STAMP2 gene were sequenced in 48 Uygur Xinjiang population with diabetes. Representative variations selected were genotyped by TaqMan-PCR method in all individuals.Results Ten noval and 6 known variations in the STAMP2 gene were identified. The distribution of genotype rs8122 significantly differed between T2DM group and control group (P =0. 05) , whereas the distribution of genotypes rsl981529 and rs34741656 showed no such difference. The fasting insulin in the total cohort and ho-meostasis model of assessment index in females showed significant difference between these two groups ( P < 0. 05 ) , while the adjusted P value showed no statistical significance (P > 0. 05 ). In the male population, the different genotypes of rs8122 variation of STAMP2 gene were not significantly different (P > 0. 05). Conclusion Three polymorphisms (rs8122, rsl981529 and rs34741656) of STAMP2 gene may be not related with T2DM in Xinjiang Uygur population.关键词
前列腺六次跨膜蛋白-2基因/遗传多态性/维吾尔族/2型糖尿病Key words
six transmembrance protein of prostate 2/genetic polymorphism/Uygur/type 2 diabetes mellitus分类
医药卫生引用本文复制引用
韩瑞梅,李南方,严治涛,郭艳英,张菊红,王红梅,洪静,周玲..前列腺六次跨膜蛋白-2基因多态性与新疆维吾尔族人糖尿病的相关性[J].中国医学科学院学报,2012,34(5):509-514,6.基金项目
国家自然科学基金(30850006) （30850006）
