中国卒中杂志2012，Vol.7Issue(9)：698-704,7.
急性缺血性卒中后抑郁危险因素的前瞻性队列研究
Risk Factors for Depression at the Acute Stage of Ischemic Stroke: A Prospective Cohort Study
摘要
Abstract
Objective To explore the independent risk factors of post-stroke depression(PSD) at the acute stage of ischemic stroke in the stroke unit in a prospective cohort study. Methods Eligible inpatients with acute ischemic cerebrovascular diseases within 14 days after onset were enrolled in this study. Demographic data, past history, associated clinical indicators and imaging data were collected. The assessments of neurological deficit and mental scale were carried out for all the enrolled patients within 14 day after onset, and according to the depression evaluation, all patients were divided into PSD group and non-PSD group. Demographic data and clinical data were compared between the two groups to analyze the risk factors for depression at the acute stage of ischemic stroke. Results Total of 268 patients were included in this study, 116 in PSD group and 152 in non-PSD group. Compared with the non-PSD group, a significantly higher proportion of patients in the PSD group were females, with a history of diabetes, and had impetuous and inward dispositions. The PSD group had significantly higher National Institutes of Health Stroke Scale(NIHSS) and lower Mini-Mental State Examination(MMSE) score than the non-PSD group on 14 days after onset. The imaging findings showed that acute infarction at basal ganglia was associated with high PSD incidence; the detection rate of encephalatrophy at bilateral medial temporal lobe, right parietal lobe, and bilateral occipital lobe were significantly higher in PSD group than that in non-PSD group. Gender(P＜0.0001, OR 7.064, 95%CI 3.334-14.966) and NIHSS score on 14 days after onset(P=0.0020, OR 1.158, 95%CI 1.055-1.272) were the independent risk factors of PSD. Easygoing disposition before onset(P=0.0264, OR 0.447, 95%CY 0.220-0.910) was a protective factor for PSD. Conclusion Female-gender and neurological deficit on 14 days after onset are independent risk factors of PSD. Easygoing disposition before onset is a protective factor for PSD.关键词
抑郁/危险因素/脑萎缩/前瞻性队列研究Key words
Depression/ Risk factor/ Encephalatrophy/ Prospective cohort study引用本文复制引用
杨中华,张宁,白莹,王安心,王展,王艳云,吴佳,王春雪..急性缺血性卒中后抑郁危险因素的前瞻性队列研究[J].中国卒中杂志,2012,7(9):698-704,7.基金项目
国家自然科学基金:识别脑区功能连接网络的研究及其在白质疏松患者认知功能障碍方面的应用(81071115)北京市自然科学基金:卒中后抑郁神经传导通路及mGluR2/3候选基因研究(7102050) （81071115）
