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Abnormal functional connectivity with mood regulating circuit in unmedicated individual with major depression: a resting-state functional magnetic resonance study

PENG Dai-hui SHEN Ting ZHANG Jie HUANG Jia LIU Jun LIU Shu-yong JIANG Kai-da XU Yi-feng FANG Yi-ru

中华医学杂志（英文版）2012，Vol.125Issue(20)：3701-3706,6.

中华医学杂志（英文版）2012，Vol.125Issue(20)：3701-3706,6.DOI:10.3760/cma.j.issn.0366-6999.2012.20.019

Abnormal functional connectivity with mood regulating circuit in unmedicated individual with major depression: a resting-state functional magnetic resonance study

PENG Dai-hui ¹SHEN Ting ²ZHANG Jie ¹HUANG Jia ¹LIU Jun ³LIU Shu-yong ⁴JIANG Kai-da ²XU Yi-feng ²FANG Yi-ru⁵

作者信息

1. Division of Mood Disorder Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
2. Clinic Medical Center Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
3. Department of Medical Imaging, Shanghai Pu tuo People's Hospital, Shanghai 200062, China
4. Department of Medical Imaging, Taian People's Hospital, Taian,Shangdong 271021, China
5. Huashan Hospital, Medical School of College, Fudan University,Shanghai 200032, China
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摘要

Abstract

Background Reports on mood regulating circuit (MRC) indicated different activities between depressed patients and healthy controls.The functional networks based on MRC have not been described in major depression disorder (MDD).Both the anterior cingulate cortex (ACC) and thalamus are all the key regions of MRC.This study was to investigate the two functional networks related to ACC and thalamus in MDD.Methods Sixteen patients with MDD on first episode which never got any medication and sixteen matched health controls were scanned by 3.0 T functional magnetic resonance imaging (fMRI) during resting-state.The pregenual anterior cingulate cortex (pgACC) was used as seed region to construct the functional network by cortex section.The thalamus was used as seed region to construct the functional network by limbic section.Paired-t tests between-groups were performed for the seed-target correlations based on the individual fisher z-transformed correlation maps by SPM2.Results Depressed subjects exhibited significantly great functional connectivity (FC) between pgACC and the parahippocampus gyrus in one cluster (size 923) including left parahippocampus gyrus (-21,-49,7),left parietal lobe (-3,-46,52) and left frontal lobe (-27,-46,28).The one cluster (size 962) of increased FC on thalamus network overlapped the precuneus near to right parietal lobe (9,-52,46) and right cingulate gyrus (15,-43,43) in health controls.Conclusions Abnormal functional networks exist in earlier manifestation of MDD related to MRC by both cortex and limbic sections.The increased functional connectivity of pgACC and decreased functional connectivity of thalamus is mainly involved in bias mood processing and cognition.

关键词

depression/anterior cingulate cortex/thalamus/functional connectivity/functional magnetic resonance imaging

Key words

depression/anterior cingulate cortex/thalamus/functional connectivity/functional magnetic resonance imaging

引用本文复制引用

PENG Dai-hui,SHEN Ting,ZHANG Jie,HUANG Jia,LIU Jun,LIU Shu-yong,JIANG Kai-da,XU Yi-feng,FANG Yi-ru..Abnormal functional connectivity with mood regulating circuit in unmedicated individual with major depression: a resting-state functional magnetic resonance study[J].中华医学杂志（英文版）,2012,125(20):3701-3706,6.

基金项目

This work was partly supported by grants from Shanghai Jiao Tong University Medical School Foundation(No.11XJ21006)and Science and Technology Commission of Shanghai Municipality(No.114119a5500). （No.11XJ21006）

中华医学杂志（英文版）

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ISSN：0366-6999

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