中华医学杂志（英文版）2012，Vol.125Issue(21)：3778-3781,4.DOI:10.3760/cma.j.issn.0366-6999.2012.21.005
Multiple factors related to detrusor overactivity in Chinese patients with benign prostate hyperplasia
Multiple factors related to detrusor overactivity in Chinese patients with benign prostate hyperplasia
LIU Ning 1MAN Li-bo 1HE Feng 1HUANG Guang-lin 1WANG Hai 1LI Gui-zhong 1WANG Jian-wei 1L(U) Yan-wei2
作者信息
- 1. Department of Urology,Beijing Jishuitan Hospital, Beijing 100035, China
- 2. Department of Statistics,Beijing Jishuitan Hospital, Beijing 100035, China
- 折叠
摘要
Abstract
Background Detrusor overactivity (DO) is a known cause of lower urinary tract symptoms and occurs in 50％-75％ of benign prostate hyperplasia (BPH) patients.We sought to investigate the clinical and urodynamic factors that are associated with the presence of DO in Chinese BPH patients.Methods Two hundred and eighty-seven consecutive patients with clinical BPH were retrospectively evaluated in this study.Each patient underwent urodynamic evaluation and completed the International Prostate Symptom Score (IPSS)and Quality of Life (QoL) questionnaire.Patients with neurological symptoms or other diseases likely to affect detrusor functions were strictly excluded.The 184 BPH patients included in the study were divided into groups according to the presence of DO as shown in urodynamic tests.Univariate analysis of factors associated with the presence of DO were performed using Student's t-test and the Mann-Whitney test; multivariate analysis used stepwise Logistic regressions.The relationship between degree of bladder outlet obstruction (BOO) and DO was also investigated using a linear-by-linear association test.Results Of 184 BPH patients,DO was present in 76 (41.3％).On univariate analysis,patients with DO were older (P=0.000),and showed smaller maximal bladder capacity (MBC,P=0.000) and voided volume (P=0.000),higher maximal detrusor pressure (P=0.000) and projected isovolumetric pressure (PIP) (P=0.005),higher Abrams-Griffiths number (P=0.000) and degree of bladder outlet obstruction (P=0.000),higher IPSS (P=0.000) and irritative IPSS subscores (P=0.000).Stepwise Logistic regression analysis showed that PIP (OR=1.012,95％ CI1.002-1.023,P=0.019),age (OR=1.030,95％ CI 1.005-1.067,P=0.059),and MBC (OR=0.993,95％ CI 0.990-0.996,P=0.000)were independent risk factors for DO in BPH patients.Linear-by-linear association tests indicated a positive linear association between DO and severity of BOO,with incidence of DO increasing with BOO grade (P=0.000).Conclusions In Chinese BPH patients,PIP,MBC,and age were independent factors affecting the presence of DO.DO incidence continuously increases with the degree of BOO.关键词
urodynamics/detrusor overactivity/benign prostatic hyperplasia/bladder outlet obstructionKey words
urodynamics/detrusor overactivity/benign prostatic hyperplasia/bladder outlet obstruction引用本文复制引用
LIU Ning,MAN Li-bo,HE Feng,HUANG Guang-lin,WANG Hai,LI Gui-zhong,WANG Jian-wei,L(U) Yan-wei..Multiple factors related to detrusor overactivity in Chinese patients with benign prostate hyperplasia[J].中华医学杂志（英文版）,2012,125(21):3778-3781,4.
