质谱学报2012，Vol.33Issue(5)：257-264,8.
基于UPLC/Q-TOF-MS不同比例人参配伍藜芦增毒的物质基础及动物毒性关联性研究
UPLC/Q-TOF-MS Based the Diversity of Toxiferous Composition of the Toxicity of Animals and in Different Combination of Veratrum Nigrum and Ginseng
摘要
Abstract
In order to study toxicity changes in different matching between the herbal ginseng and veratrum nigrum of eighteen incompatible medication in traditional medicine, the acute toxicity of mice treated with veratrum nigrum-ginseng combination of the eighteen in-compatibal (Shi Ba Fan) was explored. UPLC/TOF-MS with Principal Components Analysis (PCA) were used to analyze the same samples used in acute toxic experiment. The re- suits showed that death rate of mice was decreased in the rise of compatibility of ginseng with fixed dose of veratrum nigrum, toxicity alkaloid series such as veratrosine, veratrum alkamine, 3-angeloylzygadenine, germidine, veretramine, rubijervine were also increased. Therefore, above alkaloid series may be key factors contributed to the poisoning effect of ginseng combined with veratrum nigrum.关键词
藜芦/人参/急性毒性/UPLC/Q-TOF MSKey words
veratrum nigrum/ginseng/acute toxicity/UPLC/Q-TOF-MS分类
化学化工引用本文复制引用
杨亮,高月,王宇光,梁乾德,刘浩生,马增春,肖成荣,谭洪玲,汤响林,张伯礼..基于UPLC/Q-TOF-MS不同比例人参配伍藜芦增毒的物质基础及动物毒性关联性研究[J].质谱学报,2012,33(5):257-264,8.基金项目
国家重点基础研究发展计划(批准号:2011CB505304,2012CB518402),国家自然科学基金(批准号:81073149),北京市自然科学基金(批准号:7112110)资助 （批准号:2011CB505304,2012CB518402）
