中山大学学报（医学科学版）2012，Vol.33Issue(5)：655-659,5.
Snail表达水平预测乳腺癌新辅助化疗效果的临床价值
Snail Expression Predicts Clinical Response to Neoadjuvant Chemotherapy in Breast Cancer
摘要
Abstract
[Objective] Whether snail expression in breast cancer predicts the efficacy of neoadjuvant chemotherapy and prognosis is investigated. [Method] Immunohistochemical assay was used to detect the snail protein level of 192 breast cancer tissues obtained by core needle biopsy before neoadjuvant chemotherapy. The relationship of snail expression with clinicopathological characteristics and efficacy as well as prognosis of neoadjuvant chemotherapy was statistically analyzed. [Results] High snail expression was associated with larger primary tumor size, more lymph node metastasis, poor clinical response to neoadjuvant chemotherapy, poor disease free survival and overall survival. [Conclusion] The protein level of snail shows predictive value of the efficacy of neoadjuvant chemotherapy based on anthracyclines and prognosis in breast cancer.关键词
乳腺癌/snail/新辅助化疗Key words
breast camcer/ snail/ neoadjuvant chemotherapy分类
医药卫生引用本文复制引用
曾韵洁,曲少华,沈溪明,罗铭,聂燕,龚畅..Snail表达水平预测乳腺癌新辅助化疗效果的临床价值[J].中山大学学报（医学科学版）,2012,33(5):655-659,5.基金项目
中山大学教师培育项目(11ykpy28,11ykzd12) （11ykpy28,11ykzd12）
