中山大学学报（医学科学版）2012，Vol.33Issue(5)：693-696,4.
宫颈癌IB1期宫旁转移相关因素分析
Factors Associated with Parametrial Involvement in Stage IB1 Cervical Cancer
摘要
Abstract
[Objective] The purpose of our study was to determine possible factors associated with parametrial spread in the patients with stage IB1 cervical cancer and define parameters associated a low risk for parametrial spread, in order to identify candidates for less radical surgery. [Methods] We retrospectively reviewed 149 patients with stage IB1 cervical cancer who had undergone primary radical hysterectomy (class Ⅲ) and pelvic lymphadenectomy in our department from January 2008 to February 2011. All clinical pathological parameters including parametrial involvement were statistically analyzed in SPSS 18.0, with univariate X2test and multivariate logistic regression model. [Results] Overall, 8 (5.4%) of the 149 patients revealed parametrial spread. Tumor size, lymph vascular space invasion (LVSI), positive lymph nodes, depth of invasion, vaginal spread and uterine metastasis were significantly associated with parametrial involvement (P< 0.05). The multivariate analysis model showed positive lymph nodes (HR: 26.95, 95%CI: 2.32-313.41) and LVSI (HR: 47.6, 95% CI: 2.561-886.32) to be the independent predictors of parametrial spread. In patients with no LVSI and negative pelvic nodes, parametrial involvement was found to be 0.0% (0/88). [Conclusion] Patients with stage IB1 cervical cancer have a relatively lower risk for parametrial spread. Those who without positive lymph nodes or LVSI could be considered for less radical surgery such as modified radical hysterectomy or simple hysterectomy with pelvic lymphadenectomy. Furthermore, postoperative complications including vesical dysfunction and anorectal mobility disorders could be reduced as a resull.it will be confirmed by randomized clinical trait of large sample.关键词
宫颈癌/宫旁转移/相关分析Key words
cervical cancer/ parametrial involvement/ correlation analysis分类
医药卫生引用本文复制引用
卢淮武,王丽娟,谢玲玲,钟沅月,陆晓楣,林仲秋,周晖..宫颈癌IB1期宫旁转移相关因素分析[J].中山大学学报（医学科学版）,2012,33(5):693-696,4.基金项目
广东省自然科学基金(6021279) （6021279）
