中国中西医结合杂志2012，Vol.32Issue(11)：1492-1495,4.
中医辨证论治联合不同手术方法治疗耐克罗米芬多囊卵巢综合征的比较研究
Comparative Study on Chinese Medical Syndrome Typing and Treatment Combined Different Surgical Methods for Treating Clomiphene-resistant Polycystic Ovary Syndrome
摘要
Abstract
Objective To observe the therapeutic efficacy of Chinese medical syndrome typing and treatment combined cold needle puncture drainage operation or unipolar electrocoagulation drilling technique under laparoscope for treating clomiphene-resistant polycystic ovary syndrome ( PCOS). Methods Forty infertility patients with clomiphene-resistant PCOS were assigned to two groups using stratified random sampling method according to age, infertility time, and body mass index, 20 in each group. Patients in Group A were treated with Chinese medical syndrome typing and treatment combined cold needle puncture drainage operation, while those in Group B were treated with Chinese medical syndrome typing and treatment combined unipolar electrocoagulation drilling technique. After operation Chinese herbal treatment was administered to all patients according to syndrome typing. The serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), androgen (T), estradiol (E2), and prolactin (PRL) were determined before and after operation. The ovulation was monitored. The pregnancy rate and the pregnancy outcomes were recorded after operation. Results There was no statistical difference in the 3-month spontaneous ovulation rate or the 1 -year pregnancy rate (P >0. 05). The levels of LH, T, and PRL were significantly lower after operation than before operation in the two groups ( P < 0.05). The menstruation and ovulation were obviously improved after operation. The total ovulation rate was 95% (19/20) in Group A. Successful pregnancy occurred in 15 cases of Group A. Ovarian hyperstimulation syndrome (OHSS) occurred in 1 case of Group A. The total ovulation rate was 90% (18/20) in Group B. Successful pregnancy occurred in 13 cases of Group B. Hypovaria occurred in 1 case of Group B. Luteinized unruptured follicle (LUFS) occurred in 2 cases of Group A and 1 case of Group B. Conclusions Chinese medical syndrome typing and treatment combined cold needle puncture drainage operation or unipolar electrocoagulation drilling technique could effectively promote the ovulation. The two methods showed similar therapeutic effects.关键词
辨证论治/腹腔镜/多囊卵巢综合征/冷针穿刺放液术/单极电凝打孔术Key words
syndrome typing and treatment/ laparoscopy/ polycystic ovary syndrome/ cold needle puncture drainage operation/ unipolar electrocoagulation drilling technique引用本文复制引用
曾蕾,曾诚,陶莉莉,王慧颖,桑霞,黄洁明,吴晓贞..中医辨证论治联合不同手术方法治疗耐克罗米芬多囊卵巢综合征的比较研究[J].中国中西医结合杂志,2012,32(11):1492-1495,4.基金项目
广东省中医药管理局建设中医药强省课题(No.20111221) （No.20111221）
广东省高校重点实验室"中医女性生殖调节与安全性研究"项目开放基金课(No.ZF2011017) （No.ZF2011017）
