中国中西医结合杂志2012，Vol.32Issue(11)：1562-1565,4.
microRNA与冠心病中医证候研究
Study on microRNA and Chinese Medicine Syndromes of Coronary Artery Disease
摘要
Abstract
microRNA (miRNA) is single-stranded small non-coding RNA, which binds to the 3'untrans-lated region of the target mRNAs and negatively regulates the expression of the target mRNAs by translational inhibition or miRNA cleavage. miRNA plays an important role in regulating the occurrence and progression of coronary artery disease (CAD), and could be potential biomarkers and treatment targets of CAD. The syndrome typing is the superiority and feature for treating CAD by Chinese medicine(CM). To master the space-time qualitati-on and quantitation is the key step in improving the clinical efficacy of treating CAD. The specificity and sequence of miRNA are very similar to the dynamic space-time features of syndromes. Besides, miRNA is closely correlated with CAD. Therefore, by using miRNA microarray and bioinformatics to build CM syndrome correlated miRNA regulating networks, miRNA can be introduced to study the CM syndromes of CAD, thus providing a new angle to elucidate the essence of CM syndrome of CAD at the post-transcriptional level.关键词
microRNA/冠心病/中医证候Key words
microRNA/ coronary artery disease/ Chinese medical syndrome引用本文复制引用
王阶,虞桂..microRNA与冠心病中医证候研究[J].中国中西医结合杂志,2012,32(11):1562-1565,4.基金项目
国家自然科学基金项目(No.81173116) （No.81173116）
