中药材2012，Vol.35Issue(6)：944-948,5.
比较同一复方中用红芪与用黄芪对免疫抑制小鼠体液免疫的作用
Comparative Study of Hedysari Radix and Astragali Radix Alternative Classic Tonification Prescriptions on Humoral Immunity in Immunosuppressed Mice
摘要
Abstract
Objective:To compare the regulating effects of Hedysari Radix and Astragali Radix alternative classic tonification prescriptions on humoral immunity in immunosuppressed mice. Methods:The immunosuppressed mouse model was induced by cyclophos-phamide. The mice were administered intragastically with same dose of Hedysari Radix and Astragali Radix alternative Buzhong Yiqi Yiqi Yangxue,Yupingfeng oral liquid and Fuqi Zhihan granules for antagonistic experiments in vivo. And spleen index,HC50 ,CD19 + B lymphocyte subgroup and content of serum IL-4 were determined after treatment. Results: Both groups of Hedyseri Radix and Astragali Radix could antagonize immunosuppressive action caused by cyclophosphamide. They both could significantly raise spleen index, HC50, CD19 + B lymphocyte subgroup and content of serum IL-4 in different degree. And Yupingfeng aqueous extract of Hedysari Radix substitute Astragali Radix was better than Yupingfeng oral liquid in raising spleen index. There were no significant differences among the rest Hedysari Radix and Astragali Radix alternative groups. Conclusion: Hedysari Radix compatibility with other drugs compared with original prescription has similar role in humoral immunity regulation.关键词
红芪/黄芪/复方/免疫抑制/体液免疫Key words
Hedysari Radix/ Astragali Radix/ Compound/ Immunosuppression/ Humoral immunity分类
医药卫生引用本文复制引用
卫东锋,张李峰,程卫东,桂曼曼,李雪嫣,韦艳霞,鲍英存..比较同一复方中用红芪与用黄芪对免疫抑制小鼠体液免疫的作用[J].中药材,2012,35(6):944-948,5.基金项目
中国博士后科学基金(201003073) （201003073）
中国博士后科学基金(20090450017) （20090450017）
教育部高等学校博士点基金(200807330006) （200807330006）
