中医药信息2012，Vol.29Issue(5)：18-20,3.
乌腺金丝桃对抑郁症大鼠海马单胺类神经递质含量5-HT及5-HIAA的影响
The Effect of Hypericum Attenuatum Choisy on the Contents of 5-HT and 5-HIAA from Hippocampus Monoamine Neurotransmitters of Depressive Rats
摘要
Abstract
Objective; To study the effect of hypericum attenuatum Choisy. by surveying cerebral contents ( 5 -HT and 5 - HIAA) which exist in depressive model. Method : Establish chronic stress rats model of depression by singly housing and exposing to unpredictable stressors, and detect cerebral contents of monoamine neurotransmitters (5- HT and 5 - HIAA) with ELISA. Result;The high group of Hypericum attenuatum Choisy. (2. 88g/kg) could increase cerebral contents of 5 - HT and 5 - HIAA significantly. Conclusion;Hypericum attenuatum Choisy. plays a role of the antidepression, and the possible mechanism of hypericum attenuatum Choisy. for antidepressant effect may be involved in increasing contents of 5 - HT and 5 - HIAA.关键词
乌腺金丝桃/抗抑郁/慢性不可预计性应激抑郁模型/单胺类神经递质Key words
Hypericum attenuatum choisy/ Antidepression Chronic and unpredictable stress model of depression Monoamine neurotransmitters分类
医药卫生引用本文复制引用
李冀,吴全娥,高彦宇,石鑫,唐明哲,曹明明..乌腺金丝桃对抑郁症大鼠海马单胺类神经递质含量5-HT及5-HIAA的影响[J].中医药信息,2012,29(5):18-20,3.基金项目
国家十一五重大新药创制科技专项(2009ZX09103-302) （2009ZX09103-302）
