安徽医科大学学报2012，Vol.47Issue(12)：1436-1438,3.
盐酸吡格列酮对T2DM患者尿8-羟基脱氧鸟苷排泄的影响
Effects of hydrochloride pioglitazone on urinary 8-hydroxy-deoxyguanosine excretion in type 2 diabetics
摘要
Abstract
Objective To observe the effects of hydrochloride pioglitazone on urinary 8-hydroxy-deoxyguanosine ( 8-OHdG ) excretion in type 2 diabetics and explore its possible reno-protective mechanisms. Methods 98 uncontrolled type 2 diabetics were assigned randomly into group A ( pioglitazone add-on ) and group B ( sulfonylureas add-on). FBG, HbAlc, urinary 8-OHdG urinary albumin ( ALB ) and urinary creatinine ( Cr ) were determined respectively after 12 weeks treatment. Results Compared with pre-treatment, FBG, HbAlc and urinary 8-OHdG/ Cr ratio( U8CR ) were all obviously decreased in both therapy groups; urinary albumin/urinary creatinine ratio ( UACR ) markedly decreased in group A( P <0. 01 ), while slightly decreased in group B( P >0. 05 ) after twelve weeks observation. FBG and HbAlc showed no marked difference between group A and group B after treatment ( P >0. 05 ). UACR and U8CR in group A were significantly lower than those in group B( P < 0. 05 , P < 0. 01 ). Meanwhile, U8CR had positive correlation with UACR( r =0. 755 , P <0. 01 ). Conclusion Pioglitazone can decrease urinary 8-OHdG excretion and lighten oxidative stress in vivo in type 2 diabetics, which may play a protective role in the kidney damage.关键词
糖尿病肾病/8-羟基脱氧鸟苷/吡格列酮Key words
diabetic nephropathy/ 8-hydroxy-deoxyguanosine/ pioglitazone分类
医药卫生引用本文复制引用
王月芬,叶山东,邢燕,胡园园,赵莉丽,郑茂..盐酸吡格列酮对T2DM患者尿8-羟基脱氧鸟苷排泄的影响[J].安徽医科大学学报,2012,47(12):1436-1438,3.基金项目
安徽省卫生厅课题(编号:09A009) （编号:09A009）
