摘要
Abstract
To investigate the mechanism of the action of Jianwei Granules in the treatment of reflux esophagitis in rats . Methods A rat model of reflux esophagitis was induced . The rats with good recovery after operation were randomly divided into model group (re?0), positive control group (re?0), which was treated with enteric-coated tablets of rabeprazole sodium , and high-dose , middle-dose, and low-dose Jianwei Granule treatment groups (re?0 for each group) . In addition , 10 normal rats were assigned to normal group (re= 10 ). A piece of esophageal tissue (about 1 .5 cm in length) , which extended from the point 0 .5 cm above gastroesophageal junction toward the throat , was collected from each rat at 24 h after last administration . The esophageal tissue was subjected to pH measurement and pathological observation of mucosa . Results Compared with the normal group , the model group showed significantly decreased mucosa pH value (P<0.01), significantly increased scores on macroscopic pathological changes ( P<. 0 .01) , and significantly decreased scores (reverse score) on microscopic pathological changes (P<0 .01) . Compared with the model group, the positive control group and high-dose, middle-dose, and low-dose Jianwei Granule treatment groups showed significantly increased mucosa pH value (P<0 .05) , significantly decreased scores on macroscopic pathological changes (P<0 .01), and significantly increased scores on microscopic pathological changes (P<0 .05 or P<0 .01) . The high-dose Jianwei Granule treatment group had significantly higher mucosa pH value and scores on microscopic pathological changes than the positive control group (P<0.05). Under the light microscope, the esophageal mucosae in normal group demonstrated normal tissue structure , while those in model group demonstrated severe inflammatory cell infiltration in epithelial layer , squamous hyperplasia , and even erosion . But significant improvement in pathological changes was seen in the high-dose, middle-dose, and low-dose Jianwei Granule treatment groups , and the positive control group showed approximately the same improvement as the low -dose Jianwei Granule treatment group . Conclusion Jianwei Granules can improve the pathological morphology in rats with re -flux esophagitis , which is associated with decreasing the acidity of lower esophageal mucosa .关键词
反流性食管炎/健胃冲剂/病理形态Key words
reflux esophagitis / Jianwei Granule / pH value/ pathological morphology分类
医药卫生
