重庆医学2012，Vol.41Issue(34)：3594-3596,封2,4.DOI:10.3969/j.issn.1671-8348.2012.34.007
食管癌组织中PTEN、E-cadherin的表达及其与淋巴结转移的关系
The expression of PTEN and E cadherin in esophageal carcinoma and their correlation with lymph node metastasis
摘要
Abstract
Objective To investigate the expression and significance of Phosphatase and tensin homologue deleted on chromo some 10(PTEN) and E cadherin(E CD) in the esophageal carcinoma and its precancerous lesion. Methods The expression and in terralation of PTEN and E CD was evaluated in 50 cases of mild atypical hyperplasia and 50 case of moderate atypical hyperplasia and 50 cases of severe atypical hyperplasia and 60 cases of esophageal carcinoma by immuno his to chemical staining methods. Results The positive rates of PTEN and of E CD were significantly weaker in moderate atypical hyperplasia and severe atypical hyperpla sia and esophageal carcinoma than those in normal squamous cell of esophagus(P<0. 01). The positive rates of PTEN and E CD (22. 22% ,8. 33% )in the lymph node metastasis group respectively were significantly lower than those (75. 00%,8 3. 33%) in the non lymph node metastasis group(P<0. 05). The expression of PTEN was positively correlated with ECD(r = 0. 579,P<0. 01). And the expression of PTEN and E CD was negatively correlated with lymph node metastasis(P-<0. 01). Conclusion PTEN and E CD may play an important role in esophageal carcinoma development and lymph node metastasis. A. positive correlation is found between the expression of PTEN and E CD in esophageal carcinoma. There may be an interaction or synergic action between PTEN and E CD. Expressions of PTEN and E CD might be helpful in early diagnosis and evaluation of the biological behavior and progno sis of esophageal carcinoma.关键词
食管肿瘤/第10号染色体同源丢失性磷酸酶和张力蛋白基因/钙黏着糖蛋白类/免疫组织化学Key words
esophageal neoplasms/ PTEN/ cadherins/ immuno his to chemistry引用本文复制引用
李昌秀,罗治彬,曹友德,徐红梅,杨达荣,杨柳,吴时军,张黎..食管癌组织中PTEN、E-cadherin的表达及其与淋巴结转移的关系[J].重庆医学,2012,41(34):3594-3596,封2,4.基金项目
重庆市卫生局医学科技项目(201002433). （201002433）
