重庆医学2012，Vol.41Issue(34)：3617-3618,3625,3.DOI:10.3969/j.issn.1671-8348.2012.34.017
托吡酯与卡马西平治疗部分性癫痫发作的疗效比较
Comparsion of the efficacy of topiramate and carbamazepine in the epilepsy patients with partial seizure
谭明贤 1张书琼 1陈胜利1
作者信息
- 1. 重庆三峡中心医院神经内科,重庆万州,404000
- 折叠
摘要
Abstract
Objective To compare the efficacy and adverse effect of topiramate and carbamazepine on patients with partial sei zure. Methods We chose 200 patients with partial seizure and divided into topiramate group and carbamazepine group in random ised controlled methods. The efficacy, adverse effect and EEG were observed before and after two drugs. Results The patients with partial seizure in topiramate group had higher total effective rate and control rate,less seizure frequency than those in carbamazepine group. JNO obvious difference of EEGr variation was observed between the two groups. Some patients in topiramate group had de creased appetite,body weight degression and descending recognition function in children. And common side effect in carbamazepine group was granulopenia,and a few patients with skin lesion. Conclusion Topiramate have more efficacy in the epilepsy patients with partial seizure than carbamazepine. Topiramate could be the first line drug for partial seizure. But the change of recognition function in children must be paid attention to.关键词
癫痫/托吡酯/卡马西平/癫痫,部分性Key words
epilepsy/ topiramate/ carbamazepine/ epilepsies, partial引用本文复制引用
谭明贤,张书琼,陈胜利..托吡酯与卡马西平治疗部分性癫痫发作的疗效比较[J].重庆医学,2012,41(34):3617-3618,3625,3.
