重庆医学2012，Vol.41Issue(35)：3697-3698,3701,3.DOI:10.3969/j.issn.1671-8348.2012.35.004
改良BU/CY预处理方案行同胞相合异基因外周造血干细胞移植治疗骨髓增生异常综合征
Allogeneic peripheral blood stem cell transplantation from HLA identical sibling donor in the treatment of patients with myelodysplastic syndrome with modified BU/CY condition regimen
摘要
Abstract
Objective To assess the clinical efficacy and complications of HLA identical sibling allogeneic peripheral blood stem cell transplantation for myelodysplastic syndrome with modified BU/CY condition regimen. Methods From January 2009 to De cember 2010,5 patients with myelodysplastic syndrome received HLA identical sibling allo PBSCT in our hospital. Conditioning regimen was modified busulphan cyclophosphamide. Mycophenolate mofetil (MMF) in combination with cyclosporine (CSA) and methotrexate was used to prevent Graft versus host disease(GVHD). Results Hematopoietic reconstitution was observed in all pa tients. The time to form transplantation to neutrophil count≥0. 5X109/L and platelet ≥20X109/L were 12.4 d(range:9-14) and 13. 25 d(range:10-23)after transplantation respectively. There were 2 cases of aGVHD( T[ ] ,2 cases of limetd cGVHD,3 cases of oral ulcer,4 cases of fever including 1 patient with septicemia and 1 pulmonary infection. The other complications included 2 cases of cytomegalovirus(CMV)infections,2 hemorrhagic cystitis(HC) and 1 pure red aplastic anemia. After a follow up of median 12. 8(8 - 22) months,4 patients remained survival,and 1 case with MDS RAS resulted in relapse and died of pulmonary infectin on 7 months after transplantation. Conclusion Modified BU/CY madministration can be employed as a preparative regimen for allogene ic HSCT and shows efficacy and transplant adverse effects can be tolerated. HLA identical sibling allo PBSCT in the treatment of patients with myelodysplastic syndrome is safe and efficient.关键词
骨髓增生异常综合征/HLA相合同胞/异基因外周血造血干细胞移植/改良UB/CYKey words
myelodysplastic syndromes/ HLA identical sibling/ allogeneic peripheral blood stem cell transplantation/ modified BU/CY引用本文复制引用
张颢,陶艳玲,王志国,陈波,杨在亮,邱林,展昭民,张伯龙,马军..改良BU/CY预处理方案行同胞相合异基因外周造血干细胞移植治疗骨髓增生异常综合征[J].重庆医学,2012,41(35):3697-3698,3701,3.基金项目
黑龙江省卫生厅科研课题(2011-518) （2011-518）
哈尔滨市科技创新人才研究专项基金资助项目(2009RFQQS027). （2009RFQQS027）
