重庆医学2012，Vol.41Issue(35)：3704-3706,3.DOI:10.3969/j.issn.1671-8348.2012.35.007
小剂量来氟米特联合甲氨蝶呤治疗类风湿关节炎的临床分析
A treatment of active rheumatoid arthritis with low dose of leflunomide combined with methotrexate
摘要
Abstract
Objective To determine the efficiency of low dose leflunomide combined with methotrexate in the treatment of active rheumatoid arthritis. Methods 30 patients with active rheumatoid arthritis were ramdomized to two groups: the treatment group and control group. The patients of treatment group and control group then received low dose leflunomide combined with methotrex ate and methotrexate (7. 5 -15. 0 mg/week) alone respectively. The patients were all observed for 12 months,and the index in eludes: the main efficiency endpoint (tender and swollen joint counts, global physician and patients assessments) and the secondary efficiency endpoint (VAS,duration of morning stiffness, HAQ,C reactive protein). The ACR20, 50 were also recorded. Results After 12 months reatment, both the main efficiency and secondary efficiency index in the treatment group were better than control group(P<0. 05) ; the cases reached ACR20 standard were 80% in treatment group and 69. 2% in control group(P>0. 05) ;the ca ses reached ACR50 were 66. 7% and 38. 5% respectively(P>0. 05). Gastrointestinal reactions in treatment group were slight, with 2 cases of high blood pressure; in control group there were 2 cases of leucopenia and 2 cases of elevated liver enzymes. Conclusion Low dose of leflunomide combined with methotrexate were efficacious for active rheumatoid arthritis treatment compared with treatment with methotrexate alone, and they were well tolerated.关键词
来氟米特/甲氨蝶呤/关节炎,类风湿/生物医学研究/小剂量Key words
methotrexate/ rheumatoid arthritis/ biomedical research/ low dose/ leflunomide引用本文复制引用
王军,祖比亚,林德帅,杨俊生,覃学勇,廖明..小剂量来氟米特联合甲氨蝶呤治疗类风湿关节炎的临床分析[J].重庆医学,2012,41(35):3704-3706,3.基金项目
广西卫生厅自筹经费课题(Z2010135). （Z2010135）
