重庆医学2012，Vol.41Issue(35)：3710-3712,封2,封3,5.DOI:10.3969/j.issn.1671-8348.2012.35.009
Cyclin E、p53与PTEN在胃癌组织中的表达及临床意义
The expression of Cyclin E,p53 and PTEN in gastric carcinoma and the clinical significance
谢智惠 1王蕾 2陈进 1金琳芳3
作者信息
- 1. 苏州大学附属第四医院,普外科,江苏无锡,214062
- 2. 苏州大学附属第四医院,外科,江苏无锡,214062
- 3. 苏州大学附属第四医院,病理科,江苏无锡,214062
- 折叠
摘要
Abstract
Objective To explore the expression and significance of CyclinE,p53 ,and PTEN in gastric carcinoma. Methods Im munohistochemistry Envision two step system was used to detect the expression level of CyclinE, p53 and PTEN in sixty five gas trie cancer samples with thirteen of normal gastric tissue as a control. Results 1. The expression rate of Cyclin E in gastric cancer tissues was high,which went up with increasingly invasive depth,occurring lymphatic metastasis,and clinical stages,reduced histo logical differentiation and long distance metastasis(P-<0. 05). 2. The expression rate of p53 in gastric cancer tissues was high,and increased with increasingly invasive depth and clinical stages,reduced histological differentiation,occurring of lymphatic metastasis and long distance metastasis(P-<0. 05). 3. The expression rate of PTEN in gastric cancer tissues was low,and reduced with in creased invasive depth and clinical stages, reduced histological differentiation,occurring of lymphatic metastasis and long distance metastasis(P-<0. 05). 4. In gastric cancer,the expression of PTEN and p53,Cyclin E were of inverse correlation. The relationship between the expression of Cyclin E and p53 were negative(P<0. 05). Conclusion Cyclin E,p53 and PTEN relatively could be a marker in biological behavior of gastric cancer and estimation of prognosis, then it is suggested that combined detection may have higher accurate rate.关键词
胃肿瘤/细胞周期蛋白E/p53/磷酸酶和张力蛋白同源物基因/生物学行为Key words
stomach heoplasms/Cyclin E/p53 /PTEN/biological behavior引用本文复制引用
谢智惠,王蕾,陈进,金琳芳..Cyclin E、p53与PTEN在胃癌组织中的表达及临床意义[J].重庆医学,2012,41(35):3710-3712,封2,封3,5.
