重庆医学2012，Vol.41Issue(36)：3823-3824,3827,3.DOI:10.3969/j.issn.1671-8348.2012.36.009
胃癌组织中OPN、c-Met蛋白的异常表达及其意义
Abnormal expressions and significances of OPN and c-Met in gastric cancer
摘要
Abstract
Objective To investigate the expression of Osteopontin(OPN) and Hepatocyte growth factor acceptor (c Met) in gastric cancer tissue and their clinical significances. Methods Immunohistochemical method was used to detect the expression levels of OPN and c Met protein in 69 tissue specimens from the patients with gastric cancer, 15 cases with nontypical hyperplasia,and 10 normal gastric mucosa specimens. Results The positive rate of OPN was 69. 6% in gastric cancer,which was significantly higher than 40% in nontypical hyperplasia tissues and 20% in normal gastric mucosa(P-<0. 05). The expression of OPN protein was closely correlated to the invasive depth,TNM stage and lymph node metastasis. The positive rate of c Met was 65. 2% in gastric cancer,which was significantly higher than 26. 7% in nontypical hyperplasia tissues and 10% in normal gastric mucosa(P<0. 01). The expression of c Met protein was closely correlated to the lymph node metastasis and TNM stage. Conclusion Expression of OPN and c Met are high in gastric cancer,and there may be a synergy in the process of tumor invasion and metastasis,which may play an important role in the carcinogenesis and progression of gastric cancer.关键词
骨桥蛋白质/原癌基因蛋白质c-met/胃肿瘤Key words
osteopontin/proto oncogene proteins c met/stomach neoplasms引用本文复制引用
马桂芳,蔡红星,丁凤云,兰建云..胃癌组织中OPN、c-Met蛋白的异常表达及其意义[J].重庆医学,2012,41(36):3823-3824,3827,3.基金项目
盐城市医学科技发展计划项目(YK2011129). （YK2011129）
