重庆医学2012，Vol.41Issue(36)：3835-3836,2.DOI:10.3969/j.issn.1671-8348.2012.36.014
组织型纤溶酶原激活物在进展期大肠癌组织中的表达与微血管密度的相关性研究
A correlation research between the expression of tissue type plasminogen activator inadvanced colorectal carcinoma and microvascular density
摘要
Abstract
Objective To investigate the correlation between tissue type plasminogen activator (t PA) in advanced colorectal cancer tissue and microvessel density(MVD). Methods We selected 60 cases with advanced colorectal cancer tissue as the research group and 20 cases with normal para cancer tissues as the control group. The t PA concentration of cancer tissue extracts was detec ted by Chromogenic substrate method; the MVD was detected by immunohistochemical SP method. Results Extracts of the outer edge cancer tissue had a lower t PA concentration and a higher MVD than normal colon tissue(P<0. 01). T PA expression in cane er tissues had a negative correlation with MVD(r= - 0. 570 8,P<0. 01). Conclusion Advanced colorectal cancer could cause hy percoagulability by lowering t PA concentration,thus promoting the formation of capillaries.关键词
肠肿瘤/组织型纤溶酶原激活物/微血管密度Key words
intestinal neoplasms/tissue type plasminogen activator/ microvessel density引用本文复制引用
顾敏,孟信春,王强,杨清平..组织型纤溶酶原激活物在进展期大肠癌组织中的表达与微血管密度的相关性研究[J].重庆医学,2012,41(36):3835-3836,2.基金项目
重庆市长寿区科委基金项目(2009). （2009）
