动物学研究2012，Vol.33Issue(5)：537-541,5.DOI:10.3724/SP.J.1141.2012.05537
髓系单核细胞来源的HIV-1限制性因子——SAMHD1
SAMHD1——A HIV-1 restriction factor derived from myeloid lineage monocytes
摘要
Abstract
HIV-1 restriction factors have became one of the hottest fields of AIDS researches. In 2011, SAMHD1 was demonstrated to be a novel HIV-1 restriction factor, adding to a list of HIV-1 restriction factors that include APOBEC3G, TRIM5a and Tetherin. SAMHD1 is highly expressed in myeloid-lineage monocytes, such as macrophages and dendritic cells. In this paper, we review the current research progress on the structure of SAMHD1, its antiviral mechanism, interaction with the lentivirus Vpx, and evolution. The identification of SAMHD1 opens the door towards understanding the role of SAMHD1 in lentiviral pathogenesis.关键词
SAMHD1/HIV-1/髓系细胞/HIV-1限制因子/VpxKey words
SAMHD1/ HIV-1/ Myeloid cells/ HIV-1 restriction factor/ Vpx分类
生物科学引用本文复制引用
李佩璐,陈倩倩,张驰宇..髓系单核细胞来源的HIV-1限制性因子——SAMHD1[J].动物学研究,2012,33(5):537-541,5.基金项目
国家自然科学基金(81071391) （81071391）
江苏省自然科学基金(BK2011474) （BK2011474）
