南方医科大学学报2012，Vol.32Issue(11)：1572-1575,4.DOI:10.3969/j.issn.1673-4254.2012.11.009
CDK4蛋白在胞浆中的表达与肺癌临床病理学特征及预后的关系
Cytoplasmic expression of CDK4 protein and its correlation with the clinicopathologic features and prognosis of lung cancer
摘要
Abstract
Objective To evaluate the correlation of CDK4 protein expression in the cytoplasm with the clinicopathologic features and prognosis of lung cancer. Methods Immunohistochemistry was employed to examine CDK4 protein expression in the cytoplasm of lung cancer samples, using normal lung tissue samples as control. The correlation of cytoplasmic CDK4 protein expression with the clinicopathologic parameters and prognosis of lung cancer patients was analyzed. Results No significant difference was found in cytoplasmic CDK4 protein expression levels between lung cancer and normal lung tissues (P=1.000). In the lung cancer tissues, however, an increased cytoplasmic expression of CDK4 was positively correlated with the clinical stages and lymph node metastasis. Prognostic analysis showed that the patients with an increased cytoplasmic CDK4 expression had a markedly shorter overall survival than those with a low cytoplasmic CDK4 expression. Multivariate analysis suggested that the level of cytoplasmic CDK4 expression was an independent prognostic indicator for the survival of patients with lung cancer (P<0.001). Conclusion Overexpression of CDK4 protein in the cytoplasm may promote the carcinogenesis of lung cancer and can be an unfavorable prognostic factor for the survival of lung cancer patients.关键词
CDK4蛋白/肺癌/胞浆过表达/预后因子Key words
CDK4 protein/ lung cancer/ cytoplasmic overexpression/ prognostic factor分类
医药卫生引用本文复制引用
张月,周颖,刘真,方唯意..CDK4蛋白在胞浆中的表达与肺癌临床病理学特征及预后的关系[J].南方医科大学学报,2012,32(11):1572-1575,4.基金项目
国家自然科学基金委和广东省联合重点基金(U0732006) （U0732006）
广州市珠江科技新星计划(2011J2200009) （2011J2200009）
