南方医科大学学报2012，Vol.32Issue(11)：1623-1627,5.DOI:10.3969/j.issn.1673-4254.2012.11.022
丙泊酚与气体麻醉对老年患者术后认知功能障碍的影响:Meta分析
Effect of propofol and inhalation anesthesia on postoperative cognitive dysfunction in the elderly: a meta-analysis
摘要
Abstract
Objective To compare the effects of propofol and inhalation anesthesia on the incidence of early postoperative cognitive dysfunction (POCD) in elderly patients undergoing noncardiac surgeries. Methods PubMed, Cochrane Library, CBM, CNKI, Wanfang data and VIP Database (by October 2012) were searched for randomized controlled trials (RCTs) comparing propofol and inhalation anesthesia for their impact on the incidence of early POCD in elderly patients undergoing noncardiac surgeries. After data extraction and quality evaluation, Stata 12.0 software was used for statistical data analysis. Results Thirteen RCTs, including 2 comparing propofol with xenon, 7 comparing propofol with sevoflurane, and 4 comparing propofol with isoflurane were obtained, involving a total of 753 patients. The odds ratio of early POCD incidence between patients with propofol anesthesia and those with xenon anesthesia, sevoflurane anesthesia, and isoflurane anesthesia were 1.62 (95% CI 0.81-3.23, P=0.533), 0.67 (95% CI 0.39-1.14, P=0.830), and 0.20 (95% CI 0.08-0.50, P=0.925), respectively. Overall, the odds ratio of early POCD incidence between propofol anesthesia and inhalation anesthesia was 0.68 (95% CI 0.47-0.98, P=0.189). Egger's test showed a publication bias of the RCTs retrieved (P=0.011). Conclusion Compared with inhalation anesthesia, propofol anesthesia is associated with a lower incidence of early POCD in elderly patients, but this conclusion needs to be further verified by more well-designed large-scale RCTs.关键词
麻醉/丙泊酚/吸入麻醉/术后认知功能障碍/发生率/Meta分析Key words
anesthesia/ propofol/ inhalation anesthesia/ postoperative cognitive dysfunction/ incidence/ meta-analysis分类
医药卫生引用本文复制引用
许德奖,杨威,赵国栋..丙泊酚与气体麻醉对老年患者术后认知功能障碍的影响:Meta分析[J].南方医科大学学报,2012,32(11):1623-1627,5.基金项目
广东省自然科学基金(10151008004000007) （10151008004000007）
广东省科技计划(2010B031600153) （2010B031600153）
