法医学杂志2012，Vol.28Issue(6)：426-428,3.DOI:10.3969/j.issn.1004-5619.2012.06.006
滥用海洛因和口服可待因者尿液中吗啡和可待因的比较
Comparison of Morphine and Codeine Concentration in Urines of Heroin Abusers and Codeine Users
摘要
Abstract
Objective To compare morphine and codeine concentration in urines of heroin abusers and codeine users and to discuss the judgment index to distinguish between heroin abuser and codeine user. Methods The urines of heroin abusers and codeine users were collected at different time periods. After protein precipitation, the urine samples were conducted for the qualitative and quantitative analysis of morphine and codeine by UPLC-MS/MS. And the results were all statistically analyzed. Results Statistical analysis showed that morphine and codeine concentration in urines of heroin abusers and codeine users were both abnormal distributions. The probability of the heroin abuser would be more than 95% and less than 5% for the codeine user when the concentration of morphine in urine sample was more than 67 ng/mL. The probability of the codeine user would be more than 95% and less than 5% for the heroin abuser when the concentration of morphine in urine sample was less than 67 ng/mL. Conclusion The morphine concentration in urine could be used as a criterion to distinguish the heroin abuser from the codeine user, while the codeine concentration could not.关键词
法医毒理学/吗啡/可待因/海洛因/超高效液相色谱-串联质谱法Key words
forensic toxicology/ morphine/ codeine/ heroin/ UPLC-MS/MS分类
社会科学引用本文复制引用
卜俊,展长淑..滥用海洛因和口服可待因者尿液中吗啡和可待因的比较[J].法医学杂志,2012,28(6):426-428,3.基金项目
科研院所社会公益研究专项(GY0807) （GY0807）
